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首页> 外文期刊>Blood: The Journal of the American Society of Hematology >Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma.
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Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma.

机译：I型NKT细胞可保护（并抑制II型NKT细胞）宿主对B细胞淋巴瘤的先天性抗肿瘤免疫反应。

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摘要

Natural killer T (NKT) cells are a T-cell subpopulation known to possess immunoregulatory functions and recognize CD1d molecules. The majority of NKT cells express an invariant T-cell receptor (TCR) alpha chain rearrangement (Valpha14 Jalpha18 in mice; Valpha24 Jalpha18 in humans) and are called type I NKT cells; all other NKT cells are type II. In the current study, we have analyzed the roles for these NKT-cell subsets in the host's innate antitumor response against a murine B-cell lymphoma model in vivo. In tumor-bearing mice, we found that type I NKT cells conferred protection in a CD1d-dependent manner, whereas type II NKT cells exhibited inhibitory activity. Pro- and anti-inflammatory cytokines secreted by splenocytes from tumor-bearing mice correlated with tumor progression. Myeloid cells (CD11b(+)Gr1(+)) were present in large numbers at the tumor site and in the spleen of tumor-bearing type I NKT-deficient mice, suggesting that antitumor immunosurveillance was inhibited by CD11b(+)Gr1(+) cells. Overall, these data suggest that there are distinct roles for NKT-cell subsets in response to a B-cell lymphoma in vivo, pointing to potential novel targets to be exploited in immunotherapeutic approaches against blood cancers.
机译：天然杀伤性T细胞（NKT）是已知具有免疫调节功能并识别CD1d分子的T细胞亚群。大部分NKT细胞表达不变的T细胞受体（TCR）α链重排（小鼠中为Valpha14 Jalpha18;人中为Valpha24 Jalpha18），被称为I型NKT细胞;所有其他NKT细胞均为II型。在当前的研究中，我们已经分析了这些NKT细胞亚群在宿主体内针对小鼠B细胞淋巴瘤模型的固有抗肿瘤反应中的作用。在荷瘤小鼠中，我们发现I型NKT细胞以CD1d依赖性方式提供保护，而II型NKT细胞则表现出抑制活性。荷瘤小鼠脾细胞分泌的促炎和抗炎细胞因子与肿瘤进展有关。髓样细胞（CD11b（+）Gr1（+））大量存在于荷瘤I型NKT缺陷小鼠的肿瘤部位和脾脏中，表明CD11b（+）Gr1（+）抑制了抗肿瘤免疫监测） 细胞。总体而言，这些数据表明，NKT细胞亚群在体内对B细胞淋巴瘤的反应具有不同的作用，这表明在针对血液癌症的免疫治疗方法中可能利用的新靶标。

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