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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Small cell osteosarcoma successfully treated by high-dose ifosfamide and methotrexate, combined with carboplatin and pirarubicin
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Small cell osteosarcoma successfully treated by high-dose ifosfamide and methotrexate, combined with carboplatin and pirarubicin

机译：大剂量异环磷酰胺和甲氨蝶呤联合卡铂和吡柔比星成功治疗小细胞骨肉瘤

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摘要

Small cell osteosarcoma (SCO) is the most rare subtype of osteosarcoma and has a poor prognosis. An 11-year-old boy presented with 2-month history of painful tumefaction in the lower leg. Imaging analysis demonstrated a mixture of osteolytic and osteosclerotic lesions in the proximal tibia and extraskeletal area. Histology of the open biopsy showed small round cells producing mucous matrix. Based on these findings, SCO was suspected. The patient received three cycles of neoadjuvant chemotherapy using high-dose ifosfamide, high-dose methotrexate, pirarubicin and carboplatin. Wide-margin resection was performed followed by tibial lengthening using the Ilizarov method and two cycles of adjuvant chemotherapy with the same drugs as for neoadjuvant chemotherapy. Histology of the resected specimen showed that almost all tumor cells were necrotized. Neither recurrence nor metastasis was found after 4 years. Our experience suggests that neoadjuvant chemotherapy, such as the one used here, would be exceedingly effective for SCO without serious non-hematological toxicities.
机译：小细胞骨肉瘤（SCO）是骨肉瘤最罕见的亚型，预后较差。一个11岁的男孩在小腿出现了2个月的疼痛性肿胀病史。影像学分析显示胫骨近端和骨骼外区域混有溶骨性和骨硬化性病变。开放活检的组织学显示小圆形细胞产生粘液基质。基于这些发现，怀疑是上海合作组织。该患者接受了大剂量异环磷酰胺，大剂量甲氨蝶呤，吡柔比星和卡铂三轮新辅助化疗。进行大范围切除，然后使用Ilizarov方法进行胫骨延长术，并使用与新辅助化疗相同的药物进行两个周期的辅助化疗。切除标本的组织学表明，几乎所有肿瘤细胞都坏死了。 4年后均未发现复发或转移。我们的经验表明，新辅助化疗（如在此使用的那种）对SCO极其有效，并且没有严重的非血液学毒性。

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