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首页> 外文期刊>Annual Review of Immunology >The Immunobiology of Interleukin-27
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The Immunobiology of Interleukin-27

机译：白介素27的免疫生物学

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Interleukin-27 (11-27) is a cytokine with strikingly diverse influences on the immune response. Although it was initially linked with the development of Th1 responses, it is now- recognized as a potent antagonist of different classes of inflammation through its ability to directly modify CD4(+) and CD8(+) Teen effector functions, to induce IL-10. and to promote specialized T regulatory cell responses. Although this aspect of IL-27 biology has provided insights into how the immune system prevents hyperactivity in the setting of infectious and autoimmune inflammation, in vaccination and cancer models the stimulatory effects of IL-27 on CD8(+) cell function appear prominent. Additionally, associations between IL-27 and antibody-mediated disease have led to an interest in defining the impact of IL-27 on innate immunity and humoral responses in different disease states. The maturation of this literature has been accompanied by attempts to translate these findings from experimental models into human diseases and by efforts to define where IL-27 might represent a viable therapeutic target.
机译：白介素27（11-27）是一种细胞因子，对免疫反应的影响极为不同。尽管它最初与Th1反应的发展有关，但由于其直接修饰CD4（+）和CD8（+）青少年效应子功能以诱导IL-10的能力，现已被认为是不同类型炎症的有效拮抗剂。 。并促进专门的T调节细胞反应。尽管IL-27生物学的这一方面已经提供了有关免疫系统如何防止传染性和自身免疫性炎症反应过度活跃的见解，但在疫苗接种和癌症模型中，IL-27对CD8（+）细胞功能的刺激作用似乎很突出。此外，IL-27与抗体介导的疾病之间的关联引起了人们对确定IL-27在不同疾病状态下对先天免疫和体液反应的影响的兴趣。这些文献的成熟伴随着将这些发现从实验模型转化为人类疾病的尝试，并试图确定IL-27在哪里可以代表可行的治疗靶标。

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