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首页> 外文期刊>Brain research >Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury.
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Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury.

机译：高压氧疗法改善了慢性外伤性脑损伤大鼠模型的空间学习和记忆能力。

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In the present experiment we use a rat model of traumatic brain injury to evaluate the ability of low-pressure hyperbaric oxygen therapy (HBOT) to improve behavioral and neurobiological outcomes. The study employed an adaptation of the focal cortical contusion model. 64 Male Long-Evans rats received unilateral cortical contusion and were tested in the Morris Water Task (MWT) 31-33 days post injury. Rats were divided into three groups: an untreated control group (N=22), an HBOT treatment group (N=19) and a sham-treated normobaric air group (N=23). The HBOT group received 80 bid, 7 days/week 1.5 ATA/90-min HBOTs and the sham-treated normobaric air group the identical schedule of air treatments using a sham hyperbaric pressurization. All rats were subsequently retested in the MWT. After testing all rats were euthanized. Blood vessel density was measured bilaterally in hippocampus using a diaminobenzadine stain and was correlated with MWT performance. HBOT caused an increase in vascular density in the injured hippocampus (p<0.001) and an associated improvement in spatial learning (p<0.001) compared to the control groups. The increased vascular density and improved MWT in the HBOT group were highly correlated (p<0.001). In conclusion, a 40-day series of 80 low-pressure HBOTs caused an increase in contused hippocampus vascular density and an associated improvement in cognitive function. These findings reaffirm the clinical experience of HBOT-treated patients with chronic traumatic brain injury.
机译：在本实验中，我们使用大鼠颅脑外伤模型来评估低压高压氧治疗（HBOT）改善行为和神经生物学结果的能力。该研究采用了局灶性皮质挫伤模型的改编。 64只Long-Evans雄性大鼠接受了单侧皮质挫伤，并在受伤后31-33天接受了Morris Water Task（MWT）测试。将大鼠分为三组：未治疗的对照组（N = 22），HBOT治疗组（N = 19）和假治疗的常压空气组（N = 23）。 HBOT组接受了80次竞标，每周7天每天1.5次ATA / 90分钟HBOT，而假手术治疗的常压空气治疗组接受了相同的使用假高压加压空气治疗的时间表。随后将所有大鼠在MWT中重新测试。测试后，将所有大鼠安乐死。使用二氨基苯甲胺染色剂在海马双侧测量血管密度，并与MWT性能相关。与对照组相比，HBOT导致受伤海马的血管密度增加（p <0.001），并且在空间学习方面也有相关的改善（p <0.001）。 HBOT组的血管密度增加和MWT改善高度相关（p <0.001）。总之，一系列40天的80例低压HBOT引起了海马挫伤性血管密度的增加以及相关的认知功能改善。这些发现重申了HBOT治疗的慢性外伤性脑损伤患者的临床经验。

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