Bifunctional derivative of p,p'-dichlorochalcone. Part III. Synthesis and study for cytotoxic activity of a new compound, 2-(2,2-bis(4-chlorophenyl)ethyl)-2-(4-chlorophenyl)-thiazolidin-4-one from p,p'-dichlorochalcone.

Singh ShishuPal; Ansari WajidHusain; Lemiere Guy; Jonckers Tim; Dommisse Roger

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Bifunctional derivative of p,p'-dichlorochalcone. Part III. Synthesis and study for cytotoxic activity of a new compound, 2-(2,2-bis(4-chlorophenyl)ethyl)-2-(4-chlorophenyl)-thiazolidin-4-one from p,p'-dichlorochalcone.

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Bifunctional derivative of p,p'-dichlorochalcone. Part III. Synthesis and study for cytotoxic activity of a new compound, 2-(2,2-bis(4-chlorophenyl)ethyl)-2-(4-chlorophenyl)-thiazolidin-4-one from p,p'-dichlorochalcone.

机译：p，p'-二氯查耳酮的双功能衍生物。第三部分从对，对'-二氯查耳酮合成一种新的化合物2-（2,2-双（4-氯苯基）乙基）-2-（4-氯苯基）-噻唑烷-4-酮并进行细胞毒性研究。

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The synthesis of 2-(2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-thiazolidin-4-one (3) from p,p'-dichlorochalcone (1) via 1,3,3-tris(4-chlorophenyl)-propan-1-one (2) using thioglycollic acid in the presence of ammonium carbonate is described. Structural assignment, stereochemistry and biological assay are discussed.

机译：从p，p'-dichlorochalcone（1）通过1,3，合成2-（2,2-双（4-氯苯基）乙基] -2-（4-氯苯基）-噻唑烷-4-一（3），描述了在碳酸铵存在下使用巯基乙酸的3-三（4-氯苯基）-丙-1-酮（2），并讨论了结构归属，立体化学和生物学分析。

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来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2002年第1期|共5页
作者
Singh ShishuPal; Ansari WajidHusain; Lemiere Guy; Jonckers Tim; Dommisse Roger;
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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Antineoplastic Agents; Chalcone; Chlorobenzenes; Thiazoles; 2-(2; 2-bis(4-chlorophenyl)ethyl)-2-(4-chlorophenyl)thiazolidin-4-one; 抗肿瘤药; 查耳酮; 氯苯类; 噻唑类;

机译：Antineoplastic Agents;Chalcone;Chlorobenzenes;Thiazoles;2-(2;2-bis(4-chlorophenyl)ethyl)-2-(4-chlorophenyl)thiazolidin-4-one;抗肿瘤药;查耳酮;氯苯类;噻唑类;

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1. Bifunctional derivative of p,p'-dichlorochalcone. Part III. Synthesis and study for cytotoxic activity of a new compound, 2-(2,2-bis(4-chlorophenyl)ethyl)-2-(4-chlorophenyl)-thiazolidin-4-one from p,p'-dichlorochalcone. [J] . Singh ShishuPal, Ansari WajidHusain, Lemiere Guy, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2002,第1期

机译：p，p'-二氯查耳酮的双功能衍生物。第三部分从对，对'-二氯查耳酮合成一种新的化合物2-（2,2-双（4-氯苯基）乙基）-2-（4-氯苯基）-噻唑烷-4-酮并进行细胞毒性研究。
2. Electrochemical transformation of DDT into new 2-(Bis(4-chlorophenyl)methylene) and 2-(Bis(4-chlorophenyl)methyl)phenanthro[9,10-d][1,3]dioxoles [J] . Batanero Belen, Ramirez-Moreno Marina, Barba Fructuoso Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2016,第21期

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机译：合成，晶体结构，DFT研究，酸解离常数和甲基2-（4-氯苯基）-7a - （（4-氯苯基）氨基甲酰基）-1-氧代-5,5-二苯基-3-硫代 - 的抗微生物活性六羟基甲基-1H-吡咯[1,2-e]咪唑-6-羧酸盐
4. A Computational Study on Structural and Electronic Properties of 1 -(4-Chlorophenyl)-2-{5-(4-Chlorophenyl)-1,2,3-Oxadiazol-2-ylsulfanyl}Ethanone [C] . Pek-Lan Toh, Montha Meepripruk, Rosfayanti Rasmidi International Conference on Computational Science and Engineering . 2019

机译：1 - （4-氯苯基）-2 - {5-（4-氯苯基）-1,2,3-恶二唑-2-基磺酰基}磺酰基}磺酰基}的结构和电子性质的计算研究
5. Spectroscopic studies on carborane derivatives: Synthesis and characterization of partial cage degradation reactions of 1,2-(hydroxymethyl radical)-closo-carborane with 2-(aminomethyl)-pyridine. [D] . Gilbes, Blanca Janet. 2006

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6. Synthesis molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives [O] . Shinky Mehta, Sanjiv Kumar, Rakesh Kumar Marwaha, 2019

机译：新型2-（4-（2-氯乙酰基）哌嗪-1-基）-N-（2-（4-氯苯基）-4-氧喹唑啉-3（4H）-基）乙酰胺衍生物的合成分子对接和生物潜力
7. Bifunctional Derivative of p,p'-Dichlorochalcone. Part II. Synthesis of a Novel Compound 2-[2-Carboxymethylthio-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-4-thiazolidinone [O] . Roger Dommisse, Alex De Groot, Guy LemiÃƒÂ¨re, 1999

机译：p，p'-二氯查耳酮的双功能衍生物。第二部分新型化合物2- [2-羧基甲硫基-2-（4-氯苯基）乙基] -2-（4-氯苯基）-4-噻唑烷酮的合成

Bifunctional derivative of p,p'-dichlorochalcone. Part III. Synthesis and study for cytotoxic activity of a new compound, 2-(2,2-bis(4-chlorophenyl)ethyl)-2-(4-chlorophenyl)-thiazolidin-4-one from p,p'-dichlorochalcone.

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