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首页> 外文期刊>Genes, brain, and behavior >Social cognition and underlying cognitive mechanisms in children with an extra X chromosome: a comparison with autism spectrum disorder
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Social cognition and underlying cognitive mechanisms in children with an extra X chromosome: a comparison with autism spectrum disorder

机译：X额外染色体儿童的社会认知和潜在认知机制：与自闭症谱系障碍的比较

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Individuals with an extra X chromosome are at increased risk for autism symptoms. This study is the first to assess theory of mind and facial affect labeling in children with an extra X chromosome. Forty-six children with an extra X chromosome (29 boys with Klinefelter syndrome and 17 girls with Trisomy X), 56 children with autism spectrum disorder (ASD) and 88 non-clinical controls, aged 9-18 years, were included. Similar to children with ASD, children with an extra X chromosome showed significant impairments in social cognition. Regression analyses showed that different cognitive functions predicted social cognitive skills in the extra X and ASD groups. The social cognitive deficits were similar for boys and girls with an extra X chromosome, and not specific for a subgroup with high Autism Diagnostic Interview Revised autism scores. Thus, children with an extra X chromosome show social cognitive deficits, which may contribute to social dysfunction, not only in children showing a developmental pattern that is 'typical' for autism but also in those showing mild or late presenting autism symptoms. Our findings may also help explain variance in type of social deficit: children may show similar social difficulties, but these may arise as a consequence of different underlying information processing deficits.
机译：X染色体多余的人患自闭症症状的风险增加。这项研究是第一个评估带有额外X染色体儿童的心理和面部情感标签理论的研究。其中包括46个具有额外X染色体的儿童（29名男孩患有Klinefelter综合征，17名女孩患有X染色体三体症），56名患有自闭症谱系障碍（ASD）的儿童和88名9-18岁的非临床对照。与ASD患儿相似，X染色体额外的患儿社交认知能力明显受损。回归分析表明，不同的认知功能可以预测额外的X和ASD组的社交认知技能。具有额外X染色体的男孩和女孩的社交认知缺陷相似，而对于自闭症诊断访谈修正自闭症评分较高的亚组则没有特异性。因此，具有多余X染色体的儿童不仅在表现出自闭症“典型”的发育模式的儿童中，而且在表现出轻度或晚期出现自闭症症状的儿童中，都表现出社交认知缺陷，这可能导致社交功能障碍。我们的发现也可能有助于解释社会缺陷类型的差异：儿童可能表现出相似的社会困难，但这些可能是由于不同的潜在信息处理缺陷而引起的。

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