The estimation of patient-specific cardiac diastolic functions from clinical measurements.

Jiahe Xi; Pablo Lamata; Steven Niederer; Sander Land; Wenzhe Shi; Xiahai Zhuang; Sebastien Ourselin; Simon G Duckett; Anoop K Shetty; C Aldo Rinaldi; Daniel Rueckert; Reza Razavi; Nic P Smith

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The estimation of patient-specific cardiac diastolic functions from clinical measurements.

机译：根据临床测量结果评估患者特定的心脏舒张功能。

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An unresolved issue in patients with diastolic dysfunction is that the estimation of myocardial stiffness cannot be decoupled from diastolic residual active tension (AT) because of the impaired ventricular relaxation during diastole. To address this problem, this paper presents a method for estimating diastolic mechanical parameters of the left ventricle (LV) from cine and tagged MRI measurements and LV cavity pressure recordings, separating the passive myocardial constitutive properties and diastolic residual AT. Dynamic C1-continuous meshes are automatically built from the anatomy and deformation captured from dynamic MRI sequences. Diastolic deformation is simulated using a mechanical model that combines passive and active material properties. The problem of non-uniqueness of constitutive parameter estimation using the well known Guccione law is characterized by reformulation of this law. Using this reformulated form, and by constraining the constitutive parameters to be constant across time points during diastole, we separate the effects of passive constitutive properties and the residual AT during diastolic relaxation. Finally, the method is applied to two clinical cases and one control, demonstrating that increased residual AT during diastole provides a potential novel index for delineating healthy and pathological cases.

机译：舒张功能不全患者的一个尚未解决的问题是，由于舒张期间心室舒张功能受损，心肌硬度的估计不能与舒张期残余活性张力（AT）脱钩。为了解决这个问题，本文提出了一种从电影和带标签的MRI测量值以及左心室压力记录中估计左心室（LV）舒张期力学参数的方法，该方法将被动心肌的本构特性和舒张期残余AT分开。动态C1连续网格是根据动态MRI序列捕获的解剖结构和变形自动构建的。使用结合了被动和主动材料特性的机械模型来模拟舒张变形。重新定义该定律的特征是使用众所周知的古奇内定律的本构参数估计的非唯一性问题。使用这种重新设计的形式，并通过将舒张期间各个时间点的本构参数约束为恒定，我们可以将舒张期舒张过程中被动本构特性和残余AT的影响分开。最后，该方法被应用于两个临床病例和一个对照，证明在舒张期增加的残留AT可以为描述健康和病理病例提供潜在的新指标。

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《Medical image analysis》 |2013年第2期|共14页
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Jiahe Xi; Pablo Lamata; Steven Niederer; Sander Land; Wenzhe Shi; Xiahai Zhuang; Sebastien Ourselin; Simon G Duckett; Anoop K Shetty; C Aldo Rinaldi; Daniel Rueckert; Reza Razavi; Nic P Smith;
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中图分类影像诊断学;
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1. The estimation of patient-specific cardiac diastolic functions from clinical measurements. [J] . Jiahe Xi, Pablo Lamata, Steven Niederer, Medical image analysis . 2013,第2期

机译：根据临床测量结果评估患者特定的心脏舒张功能。
2. Dobutamine stress echocardiography Doppler estimation of cardiac diastolic function: a simultaneous catheterization correlation study. [J] . Chan AK, Govindarajan G, Del Rosario ML, Echocardiography. . 2011,第4期

机译：多巴酚丁胺负荷超声心动图多普勒估计的心脏舒张功能：同步导管相关性研究。
3. Diastolic function in pregnant patients with cardiac symptoms diastolic function in pregnancy [J] . KansalM., HibbardJ.U., BrillerJ. Hypertension in pregnancy: Official journal of the International Society for the Study of Hypertension in Pregnancy . 2012,第3期

机译：患有心脏症状的孕妇患者的舒张功能孕期舒张功能
4. Analysis of cardiac micro-acceleration signals for the estimation of systolic and diastolic time intervals in cardiac resynchronization therapy [C] . Giorgis L., Hernandez A.I., Amblard A., Computers in Cardiology, 2008 . 2008

机译：分析心脏微加速度信号以估计心脏再同步治疗中的收缩和舒张时间间隔
5. Effects of age and immune dysfunction on the cardiac extracellular matrix and diastolic function. [D] . Alwardt, Cory M. 2005

机译：年龄和免疫功能障碍对心脏细胞外基质和舒张功能的影响。
6. The estimation of patient-specific cardiac diastolic functions fromclinical measurements [O] . Jiahe Xi, Pablo Lamata, Steven Niederer, -1

机译：估计患者特异性心脏舒张功能临床测量
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The estimation of patient-specific cardiac diastolic functions from clinical measurements.

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