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Modulating effects of Allium sativum (garlic) extract in monosodh m glutamate induced injuries in rats

机译：大蒜提取物对味精对大鼠损伤的调节作用

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摘要

This study investigates the toxicity effect of monosodium glutamate (MSG) on some tissues of rats and the effect of its combined administration with garlic. Thirty five rats randomized to 5 groups were used. Group B (7 rats) was placed on MSG (200mg/Kg/day). Group C (21 rats) was simultaneously administered with MSG and garlic (260mg/Kg/day). After 28 days of continuous treatment, 7 rats were sacrificed in each group. The rest rats in group B were redistributed into groups D and E. Group D was treated with garlic. Blood was withdrawn after the next 28 days treatment period. The liver, kidney and uterus were also removed. The results indicated that MSG increased plasma cholesterol, triglyceride, LDL, atherogenic and coronary risk index, fasting bloodglucose and total protein but decreased plasma HDL. None of these parameters were altered when MSG and garlic were coadministered and when garlic was administered after MSG withdrawal. Although none of the rat's uterus showed any morphological change, significant increase in the body weight and relative organ weight were observed with MSG administration. The study suggested that MSG intake may elicit cardiovascular disorder and may also pose serious toxicological threat to cardiovascular tissues and the garlic has protective and ameliorative effect.
机译：本研究探讨了味精对大鼠某些组织的毒性作用以及与大蒜联合给药的作用。使用随机分为5组的35只大鼠。将B组（7只大鼠）置于味精（200mg / Kg /天）上。 C组（21只大鼠）同时服用味精和大蒜（260mg / Kg /天）。连续治疗28天后，每组处死7只大鼠。将B组中的其余大鼠重新分配至D组和E组。D组用大蒜处理。在接下来的28天治疗期后抽血。肝，肾和子宫也被切除。结果表明，味精可增加血浆胆固醇，甘油三酸酯，低密度脂蛋白，动脉粥样硬化和冠心病危险指数，空腹血糖和总蛋白，但降低血浆高密度脂蛋白。当同时服用味精和大蒜时以及退出味精后服用大蒜时，这些参数均未改变。尽管大鼠的子宫均未显示任何形态变化，但使用MSG可以观察到体重和相对器官重量的显着增加。研究表明，摄入味精可能会引起心血管疾病，也可能对心血管组织构成严重的毒理学威胁，大蒜具有保护和改善作用。

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