• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Amygdala-Dependent Fear Memory Consolidation via miR-34a and Notch Signaling
【24h】

Amygdala-Dependent Fear Memory Consolidation via miR-34a and Notch Signaling

机译：通过miR-34a和Notch信号进行杏仁核依赖性恐惧记忆整合

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Using an array-based approach after auditory fear conditioning and microRNA (miRNA) sponge-mediated inhibition, we identified a role for miR-34a within the basolateral amygdala (BLA) in fear memory consolidation. Luciferase assays and bioinformatics suggested the Notch pathway as a target of miR-34a. mRNA and protein levels of Notch receptors and ligands are downregulated in a time-and learning-specific manner after fear conditioning in the amygdala. Systemic and stereotaxic manipulations of the Notch pathway indicated that Notch signaling in the BLA suppresses fearmemory consolidation. Impairment of fear memory consolidation after inhibition of miR-34a within the BLA is rescued by inhibiting Notch signaling. Together, these data suggest that within the BLA, a transient decrease in Notch signaling, via miR-34a regulation, is important for the consolidation of fear memory. This work expands the idea that developmental molecules have roles in adult behavior and that existing interventions targeting them hold promise for treating neuropsychiatric disorders.
机译：听觉恐惧条件和microRNA（miRNA）海绵介导的抑制后，使用基于阵列的方法，我们确定了基底外侧杏仁核（BLA）中miR-34a在恐惧记忆巩固中的作用。萤光素酶测定和生物信息学表明，Notch途径是miR-34a的靶标。杏仁核恐惧调节后，Notch受体和配体的mRNA和蛋白质水平以时间和学习特定的方式下调。对Notch途径的系统和立体定位操作表明BLA中的Notch信号传导抑制恐惧记忆巩固。通过抑制Notch信号可以挽救BLA中的miR-34a抑制后恐惧记忆巩固的受损。总之，这些数据表明在BLA中，通过miR-34a调节，Notch信号的瞬时减少对于恐惧记忆的巩固很重要。这项工作扩展了这样的观念，即发育分子在成人行为中起作用，并且针对它们的现有干预措施有望治疗神经精神疾病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号