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首页> 外文期刊>Neuropsychologia >Neural mechanisms of encoding social and non-social context information in autism spectrum disorder
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Neural mechanisms of encoding social and non-social context information in autism spectrum disorder

机译：自闭症谱系障碍中社交和非社交情境信息编码的神经机制

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Individuals with autism spectrum disorder (ASD) often fail to attach context to their memories and are specifically impaired in processing social aspects of contextual information. The aim of the present study was to investigate the modulatory influence of social vs. non-social context on neural mechanisms during encoding in ASD. Using event-related fMRI, 13 boys with ASD and 13 typically developing boys comparable for age and IQ were investigated during encoding of neutral objects presented either with a social (faces) or a non-social (houses) context. A memory paradigm was then applied to identify brain activation patterns associated with encoding of subsequently recollected versus non-recollected objects.On the behavioural level, no significant between-group differences emerged. In particular, no differential effects of context on memory performance were observed. Neurally, however, context-specific group differences were observed in several brain regions. During encoding of subsequently recollected objects presented with a face, ASD subjects (compared to controls) showed reduced neural activation in the bilateral inferior frontal gyrus, bilateral middle frontal gyrus and right inferior parietal lobule. Neural activation in the right inferior frontal gyrus was positively correlated with memory performance in controls, but negatively in ASD individuals. During encoding of subsequently non-recollected objects presented in the non-social context, ASD subjects showed increased activation in the dorsal MPFC.Our findings suggest that in ASD subjects, fronto-parietal brain regions subserving memory formation and the association of contextual information are activated atypically when a social context is presented at encoding. The data add to findings from related research fields indicating that in ASD, socioemotional impairment extends into domains beyond social cognition. Increased activation in the dorsal MPFC in ASD individuals might reflect supervisory cognitive processes related to the suppression of a distracting non-social context.
机译：自闭症谱系障碍（ASD）的个体通常无法将上下文附加到他们的记忆中，并且在处理上下文信息的社会方面时特别受损。本研究的目的是研究在ASD编码过程中社交与非社交情境对神经机制的调节作用。使用事件相关的功能磁共振成像，在对带有社交（面部）或非社交（房屋）环境的中性对象进行编码时，对13名ASD男孩和13名典型发育中的男孩进行了年龄和智商比较。然后采用记忆范式来识别与随后收集的和未收集的对象的编码相关的大脑激活模式。在行为水平上，没有出现明显的组间差异。特别是，没有观察到上下文对内存性能的不同影响。然而，总的来说，在几个大脑区域中观察到了上下文特定的组差异。在对随后出现的带有面部表情的对象进行编码的过程中，ASD受试者（与对照组相比）显示出双侧下额回，双侧额中回和右下顶小叶的神经激活减少。右下额回的神经激活与对照组的记忆表现成正相关，而与ASD个体呈负相关。在对随后在非社交环境中出现的无法回收的物体进行编码时，ASD受试者的背侧MPFC激活增强。我们的发现表明，在ASD受试者中，顶叶顶脑区域有助于记忆形成和上下文信息的关联被激活非典型的是在编码时呈现社交环境。这些数据增加了相关研究领域的发现，表明在ASD中，社会情感障碍已扩展到社会认知范围之外。 ASD患者背侧MPFC的激活增加可能反映了与抑制分散性非社交环境有关的监督性认知过程。

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