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首页> 外文期刊>Cell metabolism >Plac8 is an inducer of C/EBPbeta required for brown fat differentiation, thermoregulation, and control of body weight.
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Plac8 is an inducer of C/EBPbeta required for brown fat differentiation, thermoregulation, and control of body weight.

机译：Plac8是棕色脂肪分化，体温调节和体重控制所需的C / EBPbeta诱导剂。

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Brown adipocytes oxidize fatty acids to produce heat in response to cold or to excessive energy intake; stimulation of brown fat development and function may thus counteract obesity. Brown adipogenesis requires activation of the transcription factor C/EBPbeta and recruitment of the zinc finger protein Prdm16, but upstream inducers of these proteins are incompletely defined. Here, we show that genetic inactivation of Plac8, a gene encoding an evolutionarily conserved protein, induces cold intolerance, and late-onset obesity, as well as abnormal morphology and impaired function of brown adipocytes. Using brown preadipocyte lines we show that Plac8 is required for brown fat differentiation, that its overexpression induces C/EBPbeta and Prdm16, and that upon induction of differentiation Plac8 associates with C/EBPbeta and binds to the C/EBPbeta promoter to induce its transcription. Thus, Plac8 is a critical upstream regulator of brown fat differentiation and function that acts, at least in part, by inducing C/EBPbeta expression.
机译：棕色脂肪细胞会因寒冷或能量摄入过多而氧化脂肪酸，从而产生热量。因此，刺激棕色脂肪的发育和功能可以抵消肥胖。棕色脂肪形成需要转录因子C / EBPbeta的激活和锌指蛋白Prdm16的募集，但这些蛋白的上游诱导剂尚未完全定义。在这里，我们显示Plac8（编码进化上保守的蛋白质的基因）的基因失活诱导了耐寒性和晚期肥胖，以及棕色脂肪细胞的异常形态和功能受损。使用棕色前脂肪细胞系，我们表明Plac8是棕色脂肪分化所必需的，其过表达诱导C / EBPbeta和Prdm16，并且在分化诱导后Plac8与C / EBPbeta缔合并结合C / EBPbeta启动子以诱导其转录。因此，Plac8是棕色脂肪分化和功能的关键上游调节剂，其至少部分通过诱导C / EBPbeta表达起作用。

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