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Strain differences in the distribution of dopamine (DA-2 and DA-3) receptor sites in rat brain

机译：大鼠脑中多巴胺（DA-2和DA-3）受体位点分布的应变差异

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The dopamine (DA) pathway mediates numerous neuronal functions which are implicated in psychiatric disorders. Previously, our lab investigated the status of the dopamine transporter in the Wistar-Kyoto rat, a purported rodent model of depressive behavior, and reported significant alterations in transporter binding sites in several brain regions when compared to control rat strains. Given that DA-2 and DA-3 receptors belong to the same class of DA receptors, are co-localized in the mesolimbic and nigrostriatal regions of the brain and function as autoreceptors, this study mapped the distribution of central DA-2 and DA-3 receptors in Wistar-Kyoto and Wistar rats. The results indicated that while the binding of I-125-sulpride to DA-2 receptors was higher in the nucleus accumbens (shell) and ventral tegmental area, it was lower in the nucleus accumbens (core), caudate putamen and hypothalamus in Wistar-Kyoto compared to Wistar rats. In contrast, the binding of I-125-sulpride to DA-3 receptors was higher in the caudate putamen, nucleus accumbens (shell and core) and islands of Calleja in Wistar-Kyoto compared to Wistar rats. Given that DA-2 like receptors in the ventral tegmental area function as autoreceptors, it is possible that the greater inhibitory effects exerted by DA-2 and DA-3 receptors in Wistar-Kyoto rats may lead to a net deficit in DA levels in areas receiving projection from this cell body area. (c) 2006 Elsevier Inc. All rights reserved.
机译：多巴胺（DA）通路介导了许多与精神疾病有关的神经元功能。以前，我们的实验室研究了Wistar-Kyoto大鼠的多巴胺转运蛋白的状态（一种据称是抑郁行为的啮齿动物模型），并报告了与对照大鼠品系相比，大脑多个区域的转运蛋白结合位点发生了显着变化。鉴于DA-2和DA-3受体属于同一类DA受体，并且共定位于大脑的中边缘和黑纹状体区域，并且可以作为自身受体，因此该研究绘制了中枢DA-2和DA- Wistar-Kyoto和Wistar大鼠中的3种受体。结果表明，虽然I-125硫化物与DA-2受体的结合在伏隔核（壳）和腹侧被盖区较高，但在伏隔核（核心），尾状壳核和下丘脑在Wistar-京都比起Wistar大鼠。相比之下，与Wistar大鼠相比，Wistar-Kyoto的尾状壳，伏隔核（壳和核）和Calleja岛中I-125硫与DA-3受体的结合更高。鉴于腹侧被盖区中的DA-2样受体起自身受体的作用，可能是Wistar-Kyoto大鼠中DA-2和DA-3受体发挥的更大抑制作用可能导致该区DA的净缺乏从该单元体区域接收投影。 （c）2006 Elsevier Inc.保留所有权利。

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