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首页> 外文期刊>Life sciences >Sennidin stimulates glucose incorporation in rat adipocytes.
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Sennidin stimulates glucose incorporation in rat adipocytes.

机译：森尼丁刺激大鼠脂肪细胞中葡萄糖的掺入。

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摘要

A novel small molecule compound which exerts insulin mimetic is desirable. Dozens of natural products that have quinone, naphthoquinone, or anthraquinone structure, were tested by a glucose incorporation assay. We found that sennidin A, anthraquinone derivative, stimulated glucose incorporation to near level of maximal insulin-stimulated and sennidin B, a stereoisomer of sennidin A, also stimulated, but the activity of sennidin B was lower than sennidin A. Sennidin A-stimulated glucose incorporation was completely inhibited by wortmannin. Sennidin A did not induce tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), but induced phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Our results suggest that in rat adipocytes, sennidin A stimulates glucose incorporation in the phosphatidylinositol 3-kinase (PI3K)- and Akt-dependent, but in the IR/IRS1-independent manner.
机译：期望一种新型的模拟胰岛素的小分子化合物。通过葡萄糖掺入测定法测试了数十种具有醌，萘醌或蒽醌结构的天然产物。我们发现蒽醌衍生物sennidin A刺激葡萄糖掺入达到最大胰岛素刺激水平，sennidin B（sennidin A的立体异构体）也被刺激，但sennidin B的活性低于sennidinA。Sennidin A刺激了葡萄糖。掺入被渥曼青霉素完全抑制。森尼丁A不会诱导胰岛素受体（IR）和胰岛素受体底物1（IRS-1）的酪氨酸磷酸化，但会诱导Akt和葡萄糖转运蛋白4（GLUT4）易位的磷酸化。我们的研究结果表明，在大鼠脂肪细胞中，sennidin A刺激葡萄糖磷脂酰肌醇3激酶（PI3K）和Akt依赖性葡萄糖的掺入，但以IR / IRS1无关的方式。

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