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首页> 外文期刊>Regulatory Toxicology and Pharmacology: RTP >Safety assessment of Cry1C protein from genetically modified rice according to the national standards of PR China for a new food resource.
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Safety assessment of Cry1C protein from genetically modified rice according to the national standards of PR China for a new food resource.

机译：根据中国国家标准，对转基因水稻中Cry1C蛋白的安全性进行了新食品资源评估。

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摘要

The Cry1C protein produced in Escherichia coli was used for in vitro evaluation and animal studies to support the safety assessment of GM food or feed products containing the Cry1C protein. The Cry1C protein does not have any sequence homology with known allergens or toxins. Although the Cry1C protein was heat stable it was rapidly degraded in vitro with simulated gastric or intestinal fluids. It did not cause adverse effects in mice as administered by gavage at a high level dosage of 5 g (Cry1C protein)/kg body weight. The mutagenicity of this protein was evaluated according to the national standards of People's Republic of China (PR China) for a new food resource. In mutagenic tests, the Cry1C protein caused<4 micronucleated cells per 1000 cells, <16 sperm abnormalities per 1000 cells and was not associated with any increased mutations in the Ames test. Taken together, these data indicate that the Cry1C protein is not a potential allergen or toxin.
机译：在大肠杆菌中产生的Cry1C蛋白用于体外评估和动物研究，以支持对含有Cry1C蛋白的转基因食品或饲料产品的安全性评估。 Cry1C蛋白与已知的过敏原或毒素没有任何序列同源性。尽管Cry1C蛋白是热稳定的，但在体外用模拟的胃液或肠液会迅速降解。通过强饲法以5 g（Cry1C蛋白）/ kg体重的高剂量给药，它不会对小鼠造成不良影响。该蛋白质的致突变性是根据中华人民共和国（中国）对一种新食品资源的国家标准进行评估的。在诱变测试中，Cry1C蛋白导致每1000个细胞<4个微核细胞，每1000个细胞<16个精子异常，并且与Ames测试中的突变增加无关。综上所述，这些数据表明Cry1C蛋白不是潜在的过敏原或毒素。

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