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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Multivariate analysis of prognostic factors in T3 N0 laryngeal carcinoma treated with total laryngectomy.
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Multivariate analysis of prognostic factors in T3 N0 laryngeal carcinoma treated with total laryngectomy.

机译：全喉切除术治疗T3 N0喉癌预后因素的多因素分析。

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OBJECTIVE: The aim of our study was to clarify the real importance of 16 possible prognostic factors analyzed retrospectively for the disease-free interval and survival of a total of 327 patients with T3 N0 M0 laryngeal carcinoma treated with total laryngectomy. METHODS: The role of each possible prognostic factor and their joint effect was explored by Cox proportional hazard survival analysis.Results and conclusions In a Cox univariate analysis for the whole group, tumor site, pattern of growth, tumor size, histologic grading, lymph node status, and the occurrence of postoperative complications were predictive of the risk of tumor recurrence. In univariate analysis, all these factors except for pattern of tumor growth, neck treatment and postoperative complications maintained their prognostic value when analyzed as predictors of survival; however, the loco-regional control of disease was the most significant one. In a Cox multivariate analysis tumor size, histologic grading and postoperative complications had a significant impact on disease-free survival, whereas only histologic grading and loco-regional failure appeared to be prognostic with a significant decrease in overall survival.
机译：目的：本研究的目的是阐明回顾性分析16种可能的预后因素对327例行全喉切除术治疗的T3 N0 M0喉癌患者的无病间隔和生存的真正重要性。方法：通过Cox比例风险生存分析探讨每种可能的预后因素及其共同作用状况和术后并发症的发生可预测肿瘤复发的风险。在单变量分析中，所有这些因素（肿瘤生长方式，颈部治疗和术后并发症除外）在作为生存预测指标时均保持其预后价值。然而，对疾病的局部控制是最重要的。在Cox多变量分析中，肿瘤大小，组织学分级和术后并发症对无病生存具有重大影响，而只有组织学分级和局部区域衰竭似乎对预后具有总体生存率的显着降低。

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