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首页> 外文期刊>Seminars in cancer biology >Towards elucidation of functional molecular signatures of the adhesive-migratory phenotype of malignant cells.
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Towards elucidation of functional molecular signatures of the adhesive-migratory phenotype of malignant cells.

机译：努力阐明恶性细胞黏附迁移表型的功能分子特征。

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摘要

Over the years, malignant transformation has been investigated on multiple levels, ranging from clinical pathology to the underlying molecular mechanisms. In "zooming in" on this process, cancer biologists have focused their attention on the molecular and cellular manifestations of the "transformed phenotype", including the genomic instability of cancer cells, their deregulated transcriptional activity, their aberrant morphology and dynamics, and the altered signaling networks activated in them. Attempts to elucidate the mechanisms underlying malignant and metastatic transformation are primarily motivated by the desire to identify specific molecules and signaling pathways that can serve as targets for novel therapies. In recent years, such studies were reinforced by major technological and conceptual developments: novel and powerful tools for genomic and proteomic analysis have been developed, and advanced computational approaches offer "systems-level" integration of rich and complex biological datasets into meaningful functional networks. In this article, we consider the current and potential impact of these new experimental approaches and, in particular, the recent progress made in quantitative proteomics, to elucidate the mechanisms underlying the "transformed phenotype". We will primarily focus on the adhesion and migration of cancer cells, and their relationships to the deregulated growth, metastatic dissemination, and anchorage independence associated with malignant transformation.
机译：多年来，已经从临床病理到潜在的分子机制等多个层面研究了恶性转化。在“放大”这一过程中，癌症生物学家将注意力集中在“转化表型”的分子和细胞表现上，包括癌细胞的基因组不稳定性，其转录活性失调，异常的形态学和动力学以及改变的其中激活了信令网络。试图阐明潜在的恶性和转移性转化机制的主要动机是希望鉴定出可以用作新疗法靶标的特定分子和信号传导途径。近年来，主要的技术和概念发展加强了此类研究：开发了用于基因组和蛋白质组分析的新颖而强大的工具，并且先进的计算方法将丰富而复杂的生物数据集“系统级”集成到有意义的功能网络中。在本文中，我们考虑了这些新实验方法的当前和潜在影响，尤其是定量蛋白质组学方面的最新进展，以阐明“转化表型”的潜在机制。我们将主要关注癌细胞的粘附和迁移，以及它们与恶性转化相关的生长失调，转移扩散和锚定独立性之间的关系。

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