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首页> 外文期刊>Synapse >Dendritic Remodeling in the Adolescent Medial Prefrontal Cortex and the Basolateral Amygdala of Male and Female Rats
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Dendritic Remodeling in the Adolescent Medial Prefrontal Cortex and the Basolateral Amygdala of Male and Female Rats

机译：雄性和雌性大鼠青春期内侧前额叶皮层和基底外侧杏仁核的树突状重塑。

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There is recent evidence of continuing development throughout adolescence in two neural areas involved in emotion and cognition, the basolateral amygdala (BLN) and the medial prefrontal cortex (mPFC). Previous research from our laboratory has demonstrated a cellular loss in both of these brain regions in rats between postnatal day (P) 35 and 90. This study investigates dendritic changes in pyramidal neurons of the BLN and Layer 5 of the mPFC at P20 (juvenile), 35 (puberty), and 90 (adulthood) in hooded rats of both sexes. Dendritic branching and dendritic spines were quantified in Golgi-Cox impregnated tissue. Between P20 and 35, dendritic length and complexity, as well as the density of dendritic spines, increased in both structures. Between P35 and 90, dendritic spines in the mPFC neurons significantly decreased in both sexes, while a loss of basilar dendrites was only detected in females. In the BLN, there was an increase in the number of branches between P35 and 90 without an increase in the total length of the dendritic tree. BLN spine density also remained stable during this period. These results show that the dendritic tree grows prior to puberty while dendritic remodeling and pruning occurs after puberty in both of these neural areas. This late development may lead to susceptibilities to psychopathologies and addictions that often develop at this time. Synapse 68:61-72, 2014.
机译：最近有证据表明，在整个青春期，涉及情感和认知的两个神经区域，即基底外侧杏仁核（BLN）和内侧前额叶皮层（mPFC）不断发展。我们实验室的先前研究表明，在出生后第35至90天之间，大鼠的这两个大脑区域均发生细胞丢失。该研究调查了在P20（幼年期）BLN的锥体神经元和mPFC的第5层的树突状变化。 ，有性别的戴头巾大鼠中分别有35岁（青春期）和90岁（成年）。在高尔基-科克斯（Golgi-Cox）浸渍的组织中定量树突分支和树突棘。在P20和35之间，两种结构的树突长度和复杂性以及树突棘的密度均增加。在P35和90之间，mPFC神经元中的树突棘在两性中均显着减少，而仅在雌性中发现了基底树突的丢失。在BLN中，P35和90之间的分支数量增加，而树状树的总长度没有增加。在此期间，BLN脊柱密度也保持稳定。这些结果表明，在这两个神经区域中，树突树在青春期之前生长，而树突重塑和修剪发生在青春期之后。这种较晚的发展可能导致对这种时候经常发展的精神病理学和成瘾症的易感性。突触68：61-72，2014。

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