• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Neurobehavioral effects of perinatal AZT exposure in Sprague-Dawley weaning rats.
【24h】

Neurobehavioral effects of perinatal AZT exposure in Sprague-Dawley weaning rats.

机译：围产期AZT暴露对Sprague-Dawley断奶大鼠的神经行为影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Because AZT (azidothymidine, zidovudine, ZDV) has become the standard of care for preventing HIV transmission during pregnancy, we conducted a study to assess the possible neurobehavioral effects of this drug, using a rat model. Each litter was randomly assigned to a treatment group: vehicle, AZT 50, 100, or 150 mg/kg, or no treatment. Treatments were administered once daily via gastric intubation, prenatally from gestation day (G) 19-22 and then postnatally from postnatal day (PND) 2-20, except the nontreated group, which was only weighed every 4 days. On PND21 each rat was given a single dose of amphetamine (0.25, 0.50, 0.75, or 1.0 mg/kg) or saline and placed in the Accuscan activity chamber for 1 h of data collection and video taping. Results show that all of the behaviors analyzed produced statistically significant main effects of perinatal treatment, challenge drug, and time block. For distance traveled, there was a significant three-way interaction between treatment, sex, and time block, an effect that was independent of the effects of handling and injecting the rats. That is, within the males, the AZT 150 group displayed the greatest amount of locomotion, while among the females, the AZT 50 group was the most active. Furthermore, the AZT 50 group showed significantly less margin time (wall hugging) and more grooming than the nontreated control group. However, handling contributed to these differences because they were not observed when the vehicle-intubated group was used as the control. Across all treatment groups, amphetamine increased locomotion, the duration of rearing, and sniffing, while it decreased wall hugging, grooming, and time spent quiet. Complex interactions between amphetamine dose and time block were also seen for each behavior. In summary, these data indicate that amphetamine, at the doses used in the current study, alters behavior in the rat at 21 days of age, and that perinatal AZT exposure alters behavior in a single domain, locomotion with the threshold for this effect depending on genders.
机译：由于AZT（叠氮胸苷，齐多夫定，ZDV）已成为预防怀孕期间HIV传播的护理标准，因此我们进行了一项研究，以大鼠模型评估了该药物可能产生的神经行为作用。将每个垃圾随机分为一个治疗组：媒介物，AZT 50、100或150 mg / kg，或不进行治疗。除未治疗组（每4天称重一次）外，每天通过胃插管一次进行治疗，从产前第19-22天开始在产前，然后从出生后2-20天从出生后第二天开始。在PND21上，给每只大鼠单剂量的苯丙胺（0.25、0.50、0.75或1.0 mg / kg）或盐水，将其置于Accuscan活动室内进行1小时的数据收集和录像。结果表明，所分析的所有行为在围产期治疗，挑战药物和时间限制方面产生了统计学上显着的主要效果。对于行进的距离，治疗，性别和时间障碍之间存在显着的三向相互作用，这种影响独立于处理和注射大鼠的影响。也就是说，在男性中，AZT 150组的运动量最大，而在女性中，AZT 50组的运动量最大。此外，与未治疗的对照组相比，AZT 50组的边缘时间（围墙时间）显着减少，修饰性更高。但是，处理导致了这些差异，因为在使用插管组作为对照组时未观察到它们。在所有治疗组中，苯丙胺均增加了运动能力，饲养和嗅觉的持续时间，同时减少了墙的拥抱，修饰和安静时间。对于每种行为，还可以看到苯丙胺剂量和时间阻滞之间的复杂相互作用。总之，这些数据表明，按当前研究使用的剂量，苯丙胺会改变21日龄大鼠的行为，而围产期AZT暴露会改变单个域的行为，其运动阈值取决于性别。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号