• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Evaluation of Neisseria Gonorrhoeae Opacity (Opa) Protein Loops as Targets for Passive Vaccination and Investigation of the Role of Opa Proteins During Infection of a Female Host
【24h】

Evaluation of Neisseria Gonorrhoeae Opacity (Opa) Protein Loops as Targets for Passive Vaccination and Investigation of the Role of Opa Proteins During Infection of a Female Host

机译：评估淋病奈瑟氏球菌不透明（Opa）蛋白质循环作为被动接种的目标和研究Opa蛋白在感染女性宿主期间的作用

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neisseria gonorrhoeae opacity (Opa) proteins mediate adherence and invasion of host cells, resistance to complement, and immunosuppression. Presented here are studies on the potential of conserved Opa protein loops as targets for passive vaccination and investigations into the role of Opa proteins during infection of the female genital tract. We demonstrated antibodies that target conserved Opa loops, the semi-variable (SV) and fourth loop (4L), recognized antigenically distinct Opa proteins. Antibodies to cyclic peptides that correspond to the SV loop (AbSV cyclic) recognized more Opa variants than antibodies generated against linear SV-loop peptides (AbSV linear). AbSV linear and AbSV cyclic, but not Ab4L linear, bound intact gonococci. AbSV cyclic, but not AbSV linear agglutinated bacteria and antibodies to a hypervariable loop 2 cyclic peptide (AbHV2BD cyclic) agglutinated and blocked interactions with cervical cells. AbHV2BD linear and AbHV2I linear were bactericidal, and this bactericidal activity was increased 8- fold when a nonhuman source of complement was used. Preincubation of Opa loop- specific antibodies with homologous variants did not protect mice from colonization; however protection studies were technically limited as 50% of the antibody was shed within one hour postadministration.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号