摘要:
目的:建立一侧肾无功能或缺失、对侧肾功能代偿患者99mTc-DTPA肾动态显像肾小球滤过率(GFR)、高峰时间(tb)及半排时间(C1/2)正常参考值范围.方法:回顾分析115例单侧肾功能正常而对侧肾缺如或无功能检查者的99mTc-DTPA肾动态显像结果,统计其GFR、显像剂摄取tb及C1/2.同时收集102例健康供肾者作为正常对照.结果:115例留存肾99mTc-DTPA肾动态显像的GFR、tb、C1/2正常参考值范围分别为(37.19~102.58)mL/min、(2.10 ~4.23) min、(6.50 ~21.51)min.无论留存肾是左肾还是右肾,两者的GFR、tb及C1/2比较差异均无统计学意义(P>0.05).留存肾GFR较供体肾代偿性增加(t=9.363,P<0.001).留存肾tb较供体肾延长(Z =3.595,P<0.001).青年组、中年组和老年组组间GFR比较差异有统计学意义(F =6.130,P=0.003),青年组和中年组留存肾较供体肾GFR分别增加了47%和37%.结论:建立留存肾功能正常检查者99mTc-DTPA显像GFR、tb、C1/2等参数的正常值参考范围,能够客观、有效地评价肾小球滤过功能,为临床诊疗提供依据.%Aim:To establish the normal reference range of compensatory residual kidney function parameters using 99mTe-DTPA renal dynamic imaging.Methods:A total of 1 15 patients with normal unilateral renal function and the contralateral kidney non-function or received nephrectomy,and 102 donors(control group) were collected.Parameters including glomerular filtration rate(GFR),the peak time of nephrogram(tb) and half time of kidney washout(C1/2) were collected.Results:The normal reference range of GFR,tb,and C1/2 in 115 cases of renal 99mTc-DTPA renal dynamic imaging were (37.19-102.58) mL/min,(2.10-4.23) min,(6.50-21.51) min,respectively.There was no significant difference in GFR,tb,and C1/2 between the residual left and the residual right kidneys(P > 0.05).GFR of the residual kidneys was statistically higher than that of donor kidneys(t =9.363,P < 0.001).The tb of the residual kidneys was statistically longer than that of normal donor kidneys(Z =3.595,P < 0.001).Compared with control group,GFR of the young group and the middle-aged group increased by 47% and 37% (F =6.130,P =0.003),respectively.Conclusion:The established normal reference range of GFR,tb,C1/2 based on 99mTc-DTPA imaging could be impersonality and efficiency to evaluate glomerular filtration function,and provide a basis for clinical diagnosis and treatment.