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Comparative Study of Glycans in Lactoferrin-a and Lactoferrin-b

机译:乳铁蛋白-A和乳铁蛋白-A中聚糖的比较研究

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In lactoferrin-a, the glycans linked to Asn-233 and Asn-545 were of the high-mannose type, whereas those present at Asn-368 and Asn-476 were complex-type ones. These glycans possessed heterogeneous structures. HPLC analyses showed that the structures of glycans linked to Asn-368, Asn-476 and Asn-545 in lactoferrin-a were very similar to those in lactoferrin-b, and that the structure of glycan linked to Asn-233 was different between lactoferrins-a and -b. In addition, the glycan bound to Asn-281 present only in lactoferrin-a was complex-type one, which possessed the heterogeneous structures including Man3GlcNAc2, Man3GlcNAc4 and Man3GlcNAc4Fuc.
机译:在乳铁蛋白-A中,与Asn-233和Asn-545连接的聚糖是高甘露糖型,而ASN-368和ASN-476的那些是复合型的。这些聚糖具有异质结构。 HPLC分析表明,与乳铁蛋白-A中的乳蛋白-A中与Asn-368,Asn-476和Asn-545的聚糖结构非常相似,与乳铁蛋白-B中的那些相似,与乳铁蛋白之间连接到Asn-233的聚糖结构不同-a和-b。此外,仅在乳蛋白-A中存在的甘共甘链蛋白是复杂的型,其具有包括Man3GlcNAc2,Man3GlcNAc4和Man3GlCNAC4Fuc在内的异质结构。

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