Objective: To explore the relationship of postpartum depression (PPD) with serum levels of prolactin ( PRL), progesterone (P) and estradiol (E2). Methods; A total of 116 parturients were evaluated depression situation with Hamilton depression scale ( HAMD - 17) before delivery and Edinburgh postnatal depression scale (EPDS) on day 42 after delivery. A-bove or equal to 13 of overall score of EPDS was the diagnosis standard of postpartum depression. Women were divided into the study group and the control group according to scores of EPDS. The serum levels of PRL, E2 and P were measured simultaneously. Results: The serum levels of P and E2 in the study group were significantly lower than those of the control group ( P all <0.05) , while there was no statistically significant difference in the serum PRL level between the two groups (P >0. 05). The changes of serum concentrations of E2 and P showed a positive correlation with EPDS scale scores ( P < 0.05 ). Conclusion : The changes of serum levels of E2 and P could be one of reasons for postpartum depression.%目的:研究分娩前后血清催乳素(PRL)、雌二醇(E2)、孕酮(P)水平变化与产后抑郁症的关系.方法:对116例产妇于产前、产后42d进行调查,产前利用汉密尔顿抑郁量表评定排除产前抑郁症,产后42d用爱丁堡产后抑郁量表(EPD5)评定,以EPDS总分≥13分为产后抑郁症诊断标准,并分别于产前、产后42d采用放射免疫方法测定血清PRL、E2及P水平.结果:抑郁组(23例)的E2、P水平均较对照组低(P＜0.05),而两组间PRL水平变化比较无统计学差异(P＞0.05)；血清E2与P水平变化与EPDS分值均呈正相关(P＜0.05).结论:分娩前后E2、P水平的改变可能与产后抑郁症的发生有关.
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