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首页> 外文期刊>The Application of Clinical Genetics >A comparison of the genetic and clinical profile of men that respond and do not respond to the immediate antihypertensive effects of aerobic exercise
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A comparison of the genetic and clinical profile of men that respond and do not respond to the immediate antihypertensive effects of aerobic exercise

机译：有氧运动对立即降压作用有反应和无反应的男性的遗传和临床特征比较

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Abstract: We compared the genetic and clinical profile of men who lower and do not lower blood pressure (BP) after acute aerobic exercise. Volunteers were 45 men (Mean ± SEM, 43.5 ± 1.5 yr) with high BP (145.7 ± 1.5/85.7 ± 1.1 mmHg). They completed three experiments: nonexercise control and two cycle exercise sessions at 40% and 60% peak oxygen consumption, and were then instrumented to an ambulatory BP monitor. Logistic regression determined the genetic and clinical profile of men who lowered BP after exercise (responders [ExR n = 36]); and those who did not (nonresponders [ExNR n = 9]). ExR had higher C-reactive protein (CRP), high-density lipoprotein (HDL), the metabolic syndrome, family history of hypertension, more renin-angiotensin system (RAS) common alleles, and α-adducin Trp460 and endothelial nitric oxide synthase (ENOS) C786 risk alleles. ExNR had lower CRP and HDL, did not have the metabolic syndrome and a family history of hypertension, had more RAS risk alleles, and had the α-adducin Gly460Gly and ENOS T786T genotypes. This model had a sensitivity of 97.1%, specificity of 75.0%, and accounted for 46.3%–74.4% of the BP response. These results suggest genetic and clinical information may eventually be used to characterize people who do and do not respond to exercise as antihypertensive therapy.
机译：摘要：我们比较了有氧运动后降低和不降低血压（BP）男性的遗传和临床特征。志愿者为45名男性（平均±SEM，43.5±1.5岁），血压高（145.7±1.5 / 85.7±1.1 mmHg）。他们完成了三个实验：非运动控制和两个峰值氧消耗为40％和60％的循环运动，然后将其安装到动态BP监护仪上。 Logistic回归确定了运动后血压降低的男性的遗传和临床特征（响应者[ExR n = 36]）;和那些没有的人（无响应者[ExNR n = 9]）。 ExR具有更高的C反应蛋白（CRP），高密度脂蛋白（HDL），代谢综合征，高血压家族史，更多的肾素-血管紧张素系统（RAS）常见等位基因以及α-adducinTrp460和内皮型一氧化氮合酶（ ENOS）C786风险等位基因。 ExNR的CRP和HDL较低，没有代谢综合征和高血压家族病史，有更多的RAS风险等位基因，并且具有α-adducinGly460Gly和ENOS T786T基因型。该模型的敏感性为97.1％，特异性为75.0％，占BP反应的46.3％–74.4％。这些结果表明，遗传和临床信息最终可用于表征对运动有反应和无反应的人作为抗高血压疗法。

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