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首页> 外文期刊>Translational psychiatry. >Back-translating behavioral intervention for autism spectrum disorders to mice with blunted reward restores social abilities
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Back-translating behavioral intervention for autism spectrum disorders to mice with blunted reward restores social abilities

机译：孤独症谱系障碍的回译行为干预对奖励迟钝的小鼠恢复了社交能力

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The mu opioid receptor (MOR) plays a critical role in modulating social behavior in humans and animals. Accordingly, MOR null mice display severe alterations in their social repertoire as well as multiple other behavioral deficits, recapitulating core and secondary symptoms of autism spectrum disorder (ASD). Such behavioral profile suggests that MOR dysfunction, and beyond this, altered reward processes may contribute to ASD etiopathology. Interestingly, the only treatments that proved efficacy in relieving core symptoms of ASD, early behavioral intervention programs, rely principally on positive reinforcement to ameliorate behavior. The neurobiological underpinnings of their beneficial effects, however, remain poorly understood. Here we back-translated applied behavior analysis (ABA)-based behavioral interventions to mice lacking the MOR (Oprm1?/?), as a model of autism with blunted reward processing. By associating a positive reinforcement, palatable food reward, to daily encounter with a wild-type congener, we were able to rescue durably social interaction and preference in Oprm1?/? mice. Along with behavioral improvements, the expression of marker genes of neuronal activity and plasticity as well as genes of the oxytocin/vasopressin system were remarkably normalized in the reward/social circuitry. Our study provides further evidence for a critical involvement of reward processes in driving social behavior and opens new perspectives regarding therapeutic intervention in ASD.
机译：mu阿片受体（MOR）在调节人类和动物的社交行为中起关键作用。因此，MOR空小鼠显示出其社交功能以及其他多种行为缺陷的严重改变，概括了自闭症谱系障碍（ASD）的核心和继发症状。这种行为特征表明，MOR功能障碍，以及除此之外，改变的奖赏过程可能有助于ASD的病因学。有趣的是，在早期的行为干预方案中，唯一可证明能缓解ASD核心症状的方法主要依靠积极的强化来改善行为。然而，关于它们的有益作用的神经生物学基础仍然知之甚少。在这里，我们将基于应用行为分析（ABA）的行为干预回译为缺乏MOR（Oprm1？/？）的小鼠，作为自闭症模型的奖励处理不完善。通过将积极的强化，可口的食物奖励与野生型同类动物的日常接触相关联，我们能够持久地挽救Oprm1？/？中的社交互动和偏好。老鼠。随着行为的改善，在奖励/社交回路中，神经元活动和可塑性标记基因的表达以及催产素/加压素系统的基因都显着标准化。我们的研究为奖励过程在推动社会行为中的重要参与提供了进一步的证据，并为ASD中的治疗干预开辟了新的视角。

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