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首页> 外文期刊>Journal of Autism and Developmental Disorders >Relation of Melatonin to Sleep Architecture in Children with Autism
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Relation of Melatonin to Sleep Architecture in Children with Autism

机译：褪黑素与自闭症儿童睡眠结构的关系

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Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM). We therefore investigated the relationship between 6-SM levels and sleep architecture in children with autism spectrum disorders (ASD). Twenty-three children, aged 4–10 years, completed two nights of polysomnography and one overnight urine collection for measurement of urinary 6-SM excretion rate. Parents completed the Children’s Sleep Habits Questionnaire. We found that higher urinary 6-SM excretion rates were associated with increased N3 sleep, decreased N2 sleep, and decreased daytime sleepiness. The results warrant further examination to examine the effects of supplemental melatonin on sleep architecture and daytime sleepiness.
机译：自闭症儿童经常患有睡眠障碍，并且与年龄相匹配的对照组相比，褪黑激素水平降低，这主要由褪黑激素主要代谢产物6-磺酰氧基褪黑激素（6-SM）所致。因此，我们调查了自闭症谱系障碍（ASD）儿童的6-SM水平与睡眠结构之间的关系。 23个4至10岁的儿童完成了两个晚上的多导睡眠图检查和一个夜间尿液收集，以测量尿中6-SM的排泄率。父母填写了《儿童睡眠习惯问卷》。我们发现较高的尿液6-SM排泄率与N3睡眠增加，N2睡眠减少和白天嗜睡减少有关。结果值得进一步检查，以检查补充褪黑激素对睡眠结构和白天嗜睡的影响。

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