摘要:Objective Urine neopterin levels and PBMC proliferating activity in psoriatic patients were studied. The relationship between urine neopterin levels and PBMC proliferating activity was analyzed. Methods The psoriatic patients were divided into groups according to disease duration. H-methyl thymidine (3 H-TdR) mixed method was used to determine proliferating activity of PBMC. ELISA was used to determine urine neopterin concentration. Thirty-one patients and thirty healthy volunteers were included in the present study. Results Urine neopterin levels in psoriatic group elevated significantly compared with control group (p < 0.01 ). In thirteen psoriatic patients within three months' duration, urine neopterin levels were positively correlated with proliferating activity of PBMC ( r = 0.594, p < 0.05 ), PASI ( r = 0. 770, p < 0.001 ) and disease duration ( r = 0. 563, p < 0. 05).In eleven psoriatic patients with over two year disease duration, however, urine neopterin levels were not significantly different from those in control group, not correlated with PBMC proliferating activity (r= 0.007) PASI (r=0.022), and disease duration (r = 0.0351, p > 0.05). Conclusions In early stage of psoriasis, urine neopterin levels may reflect proliferating activity of PBMC, and may be an index of disease severity.%目的了解银屑病患者尿新喋呤水平与外周血单个核细胞增殖活性的关系.方法采用3H-胸腺嘧啶核苷掺入法测定外周血单个核细胞(PBMC)增殖活性.用酶联免疫吸附竞争法测定尿新喋泠浓度.结果31例寻常型银屑病患者组尿新喋呤水平明显高于对照组(P<0.01).其中病程小于3个月13例患者尿新喋呤水平与PBMC增殖活性(r=0.594,P<0.05),PASI(r=0.770,P<0.001)和病程(r=0.563,P<0.05)呈显著正相关.其中病程大于2年的11例患者尿新喋呤水平与对照组无显著差别,与PBMC增殖活性(r=0.007),PASI(r=0.022)和病程(r=-0.351,P>0.05)无明显相关.结论在银屑病早期尿新喋呤水平可能反映PBMC增殖活性,可能也是反映病情轻重变化的一个指标.