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Functional genomics and the development of pathogenesis-targeted therapies for Kaposi's sarcoma.

机译:功能基因组学和针对卡波西氏肉瘤的病原性靶向疗法的发展。

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摘要

Kaposi's sarcoma (KS) is a multifocal angioproliferative disorder affecting the skin, mucosa and viscera of individuals infected with human herpesvirus-8 (HHV-8; also Kaposi's sarcoma-associated herpesvirus [KSHV]). KS is the most common neoplasm in AIDS patients; the clinical outcome of AIDS-KS is significantly improved by highly active antiretroviral therapy (HAART). However, in Africa, where the severest manifestations of KS occur, there is limited access to these and other effective but expensive drugs. Here we present a review of current efforts to identify novel therapeutic targets for the treatment of KS using functional genomics, with recommendations regarding the development of economically feasible treatments for use in Africa.
机译:卡波西氏肉瘤(KS)是一种多灶性血管增生性疾病,影响感染人类疱疹病毒8(HHV-8;也是卡波西氏肉瘤相关疱疹病毒[KSHV])的个体的皮肤,粘膜和内脏。 KS是艾滋病患者中最常见的肿瘤。高效抗逆转录病毒疗法(HAART)可显着改善AIDS-KS的临床疗效。但是,在非洲,KS表现最严重,因此获得这些药物和其他有效但昂贵的药物的机会有限。在这里,我们介绍了当前为确定使用功能基因组学治疗KS的新治疗靶点所做的努力,并就发展用于非洲的经济可行治疗方法提出了建议。

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