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首页> 外文期刊>Histology and histopathology >Expression of histone deacetylases 1, 2 and 3 in histological subtypes of testicular germ cell tumours.
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Expression of histone deacetylases 1, 2 and 3 in histological subtypes of testicular germ cell tumours.

机译：组蛋白脱乙酰基酶1、2和3在睾丸生殖细胞肿瘤的组织学亚型中的表达。

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摘要

In this study we aimed to evaluate the protein expression of class I histone deacetylases (HDAC) in testicular germ cell tumours (GCT) and to analyse differences between the histological subtypes of testicular GCT. 325 testicular GCT were included in a tissue microarray with each histological subtype of the tumour being separately represented on this array. Expression of class I HDAC isoforms 1, 2 and 3 was assessed by immunohistochemistry. While HDAC2 and 3 were highly expressed in all histological subtypes of GCT, HDAC1 was almost consistently expressed at lower levels. We observed significant differences in the expression of the respective HDACs between seminoma and non-seminoma GCT tissue components. Interestingly, choriocarcinomas showed generally high expression values for all three class I HDAC isoforms. Relevant correlations with clinicopathological parameters could not be demonstrated. Contrasting published findings on other tumour entities, no immediate practical diagnostic or prognostic value for HDAC1-3 in GCT could be inferred. However, the high expression levels might still be indicative for a treatment response to HDAC inhibitors which ought to be evaluated in further studies.
机译：在这项研究中，我们旨在评估睾丸生殖细胞肿瘤（GCT）中I类组蛋白脱乙酰基酶（HDAC）的蛋白质表达，并分析睾丸GCT组织学亚型之间的差异。 325个睾丸GCT被包括在组织微阵列中，肿瘤的每种组织学亚型在该阵列上分别表示。通过免疫组织化学评估I类HDAC同工型1、2和3的表达。虽然HDAC2和3在GCT的所有组织学亚型中均高表达，但HDAC1几乎始终以较低水平表达。我们观察到精原细胞瘤和非精原细胞瘤GCT组织成分之间各自HDACs表达的显着差异。有趣的是，绒毛膜上皮癌对于所有三种I类HDAC同工型通常显示出高表达值。与临床病理参数的相关性无法证明。与其他肿瘤实体的已发表发现相反，无法推断出GCT中HDAC1-3的即时实用诊断或预后价值。但是，高表达水平仍可能指示对HDAC抑制剂的治疗反应，应在进一步研究中进行评估。

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