• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Joint, bone, spine : >Percutaneous inoculated rabbit model of intervertebral disc space infection: magnetic resonance imaging features with pathological correlation.
【24h】

Percutaneous inoculated rabbit model of intervertebral disc space infection: magnetic resonance imaging features with pathological correlation.

机译：经皮接种的椎间盘间隙感染兔子模型：具有病理相关性的磁共振成像特征。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: The aims of this study were to characterize MRI features in percutaneously inoculated spondylodiscitis rabbit models, to evaluate MRI for non-invasive diagnosis, and to assess the incremental information brought by the use of gadolinium-enhanced MR sequences. METHODS: Under fluoroscopic control, lumbar discs of 12 New Zealand White adult rabbits were injected with bacterial suspension. Five, 10 and 15 days after bacterial inoculation, T1 and T2 signal abnormalities and contrast enhancement of discs, vertebrae and epidural spaces were evaluated. Bacteriological and pathological analyses were realized after completion of imaging series. RESULTS: Disc space infections were present in all animals. MRI detected vertebral and discal abnormalities as soon as, respectively, 5 and 10 days after inoculation. Gadolinium-enhanced sequences allowed an earlier diagnosis, a more precise evaluation of the extent of the infection and the identification of epidural involvement. The signal of vertebrae was a more reliable criterion for infection evaluation that discal one. CONCLUSIONS: MRI is a reliable tool for non-invasive diagnosis of vertebral infection in a rabbit model and can be useful to compare the efficiency of different antimicrobial therapy in animal series before human administration. Gadolinium-enhanced MR sequences allow an earlier and more precise determination of the presence and extent of infection. Modifications of vertebral signal are the more reliable criterion for the evaluation of disc spaces infection.
机译：目的：本研究的目的是表征经皮接种的脊椎盘炎兔模型的MRI特征，评估MRI的非侵入性诊断以及评估使用g增强MR序列所带来的增量信息。方法：在荧光镜控制下，对12只新西兰白成年兔的腰椎间盘注射细菌悬液。细菌接种后五天，十天和十五天，评估了椎间盘，椎骨和硬膜外间隙的T1和T2信号异常以及对比增强。完成成像系列后，进行细菌学和病理学分析。结果：所有动物均存在椎间盘间隙感染。 MRI分别在接种后5天和10天发现椎骨和椎间盘异常。 sequences增强的序列可以更早地诊断，更精确地评​​估感染的程度并确定硬膜外受累。椎间盘信号是一种较可靠的感染评估标准，可说是盘算的。结论：核磁共振成像是在兔模型中无创诊断椎骨感染的可靠工具，可用于在人类给药之前比较动物系列中不同抗菌药物治疗的效率。 d增强的MR序列可以更早，更精确地确定感染的存在和程度。椎间盘信号的改变是评估椎间盘感染的更可靠标准。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号