Dissecting the human spliceosome through bioinformatics and proteomics approaches

Graziela Mie; Sandro Jose De Souza

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Dissecting the human spliceosome through bioinformatics and proteomics approaches

机译：通过生物信息学和蛋白质组学方法解剖人类剪接体

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The precise excision of introns from mRNAs is executed by the spliceosome, a cellular machinery composed by five small nuclear RNAs and hundreds of proteins. In the last few years, several groups have used proteomics and computational biology tools to characterize the components of the human spliceosome. These reports have identified basically all known splicing factors and several new proteins. The composition of the human spliceosome confirms the link between splicing and other steps in gene expression. Here we comment on these reports and discuss the perspectives for the coming years.

机译：内含子从mRNA中的精确切除是由剪接体执行的，剪接体是由五个小核RNA和数百种蛋白质组成的细胞机制。在最近几年中，数个小组使用蛋白质组学和计算生物学工具来表征人类剪接体的成分。这些报告已经鉴定出基本上所有已知的剪接因子和几种新的蛋白质。人剪接体的组成证实了剪接和基因表达中其他步骤之间的联系。在这里，我们对这些报告进行评论，并讨论未来几年的观点。

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《Journal of Bioinformatics and Computational Biology》 |2004年第4期|共8页
作者
Graziela Mie; Sandro Jose De Souza;
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正文语种 eng
中图分类细胞生物学;
关键词
alternative splicing; spliceosome; bioinformatics; proteomics; transcriptome;

机译：剪接;剪接体;生物信息学;蛋白质组学;转录组;

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1. Dissecting the human spliceosome through bioinformatics and proteomics approaches [J] . Graziela Mie, Sandro Jose De Souza Journal of Bioinformatics and Computational Biology . 2004,第4期

机译：通过生物信息学和蛋白质组学方法解剖人类剪接体
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Dissecting the human spliceosome through bioinformatics and proteomics approaches

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