Anti-AIDS agents. Part 47:(dagger) synthesis and anti-HIV activity of 3-substituted 3',4'-Di-O-(S)-camphanoyl-(3'R,4'R)-(+)-cis-khellactone derivatives.

Xie L; Allaway G; Wild C; Kilgore N; Lee K

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Anti-AIDS agents. Part 47:(dagger) synthesis and anti-HIV activity of 3-substituted 3',4'-Di-O-(S)-camphanoyl-(3'R,4'R)-(+)-cis-khellactone derivatives.

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Anti-AIDS agents. Part 47:(dagger) synthesis and anti-HIV activity of 3-substituted 3',4'-Di-O-(S)-camphanoyl-(3'R,4'R)-(+)-cis-khellactone derivatives.

机译：抗艾滋病剂。第47部分：3-取代的3'，4'-Di-O-（S）-樟脑酰基-（3'R，4'R）-（+）-顺式-甲壳素衍生物的（匕首）合成和抗HIV活性。

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Six 3-substituted 3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone derivatives (3-8) were synthesized from 3-methyl DCK (2). 3-Hydroxymethyl DCK (6) exhibited potent anti-HIV activity in H9 lymphocytes with EC(50) and TI values of 1.87x10(-4) &mgr;M and 1.89x10(5), respectively. These values are similar to those of DCK and better than those of AZT in the same assay.

机译：从3-甲基DCK（2）合成了六个3'取代的3'，4'-di-O-（S）-樟脑酰基-（+）-顺式-甲壳酮衍生物（3-8）。 3-羟甲基DCK（6）在H9淋巴细胞中表现出有效的抗HIV活性，其EC（50）和TI值分别为1.87x10（-4）M和1.89x10（5）。这些值与DCK的值相似，并且在同一试验中优于AZT的值。

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《Bioorganic and Medicinal Chemistry Letters》 |2001年第17期|共3页
作者
Xie L; Allaway G; Wild C; Kilgore N; Lee K;
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正文语种 eng
中图分类药学;生物化学;
关键词
ANTI; HIV; Physical activity; Commonwealth of Independent States; derivatives; 独立国家联合体;

机译：ANTI;HIV;Physical activity;Commonwealth of Independent States;derivatives;独立国家联合体;

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1. Anti-AIDS agents. Part 47:(dagger) synthesis and anti-HIV activity of 3-substituted 3',4'-Di-O-(S)-camphanoyl-(3'R,4'R)-(+)-cis-khellactone derivatives. [J] . Xie L, Allaway G, Wild C, Bioorganic and Medicinal Chemistry Letters . 2001,第17期

机译：抗艾滋病剂。第47部分：3-取代的3'，4'-Di-O-（S）-樟脑酰基-（3'R，4'R）-（+）-顺式-甲壳素衍生物的（匕首）合成和抗HIV活性。
2. Anti-AIDS Agents. 52. Synthesis and Anti-HIV Activity of Hydroxymethyl (3'R,4'R)-3',4'-Di-O-(S)-camphanoyl-(+)-cis-khellactone Derivatives [J] . Lan Xie, Carl Wild, Graham Allaway, Journal of Medicinal Chemistry . 2004,第3期

机译：抗艾滋病毒剂。 52.羟甲基（3'R，4'R）-3'，4'-二-O-（S）-樟脑酰基-（+）-顺式-甲壳素衍生物的合成及抗HIV活性
3. Anti-AIDS agents. 42. Synthesis and anti-HIV activity of disubstituted (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone analogues. [J] . Xie L, Takeuchi Y, Cosentino LM, Journal of Medicinal Chemistry . 2001,第5期

机译：抗艾滋病剂。 42.二取代的（3'R，4'R）-3'，4'-二-O-（S）-樟脑酰基-（+）-顺式-甲壳酮类似物的合成和抗HIV活性。
4. Synthesis and toxicological activity of 5-nitroindazole sulfonamides derivatives as potential antimicrobial agents. Optimization of the synthesis [C] . Corina Cheptea, Andreea-Celia Benchea, Marius Găină, 2017 E-Health and Bioengineering Conference . 2017

机译：5-硝基吲唑磺酰胺衍生物作为潜在抗菌剂的合成及其毒理活性。优化合成
5. Synthesis and Structure-Activity Relationship Studies of Cyclotriaza Compounds as CD4 Down-Modulators and Anti-HIV Agents. [D] . Chawla, Reena. 2014

机译：Cyclotriaza化合物作为CD4下调剂和抗HIV剂的合成及构效关系研究。
6. Anti-AIDS Agents 82: Synthesis of Seco-(3′R4′R)-3′4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) Derivatives as Novel Anti-HIV Agents [O] . Jian Tang, Keduo Qian, Bei-Na Zhang, -1

机译：抗助剂剂82：Seco-（3R4R）-34-di-O-（s）-camphanoyl - （+） - 顺式 - khellactone（DCK）衍生物作为新型抗-HIV代理人
7. Development and Preclinical Studies of Broad-Spectrum Anti-HIV Agent (3′R,4′R)-3-Cyanomethyl-4-methyl-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-Cyanomethyl-4-methyl-DCK) [O] . Lan Xie, Huan-Fang Guo, Hong Lu, 2008

机译：广谱抗HIV试剂（3'R，4'R）-3-氰基甲基-4-甲基-3'，4'-DI-O-（S）-Camphanoyl - （+）的开发和临床前研究 - CIS-KHELLACTONE（3-氰基甲基-4-甲基-DCK）

Anti-AIDS agents. Part 47:(dagger) synthesis and anti-HIV activity of 3-substituted 3',4'-Di-O-(S)-camphanoyl-(3'R,4'R)-(+)-cis-khellactone derivatives.

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