• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation, characterisation and evaluation of curcumin with piperine-loaded cubosome nanoparticles
【24h】

Preparation, characterisation and evaluation of curcumin with piperine-loaded cubosome nanoparticles

机译：胡椒碱负载的立方纳米粒子制备姜黄素，表征及评价

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: In this study, curcumin was designed into the nanoformulation called cubosome with piperine in order to improve oral bioavailability and tissue distribution of curcumin. Methods: The characteristic of the cubosome was studied by using scanning electron microscope (SEM), Infrared spectrum and small angle X-ray scattering (SAXS) techniques. Tissue distribution of cubosome was measured by liquid chromatography-mass spectrometry (LC-MS) method in mice. Results: The characteristic of the cubosome was demonstrated that the curcumin and piperine were encapsulated in the interior of the cubosome and the crystal form was Pn3m space. The pharmacokinetic test revealed that the cubosome could improve the oral bioavailability significantly compared to the suspension of curcumin with piperine and be mainly absorbed by the spleen. Conclusion: These findings provide the reference to a preferable choice of the curcumin formulation and contribute to therapeutic application in clinical research.
机译：目的：在这项研究中，姜黄素被设计成与胡椒碱的纳米制剂，称为cubosome，以改善姜黄素的口服生物利用度和组织分布。方法：利用扫描电子显微镜（SEM），红外光谱和小角度X射线散射（SAXS）技术研究了立方脂质体的特性。通过液相色谱-质谱法（LC-MS）在小鼠中测量立方脂质体的组织分布。结果：该方糖体的特征表明姜黄素和胡椒碱被包裹在该方糖体的内部，其晶体形式为Pn3m空间。药代动力学测试表明，与姜黄素与胡椒碱的混悬液相比，cubosome可以显着提高口服生物利用度，并且主要被脾脏吸收。结论：这些发现为姜黄素制剂的优选选择提供了参考，并有助于临床研究中的治疗应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号