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首页> 外文期刊>Journal of Nutritional Science and Vitaminology >[6]-Gingerol Induces Electrogenic Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1
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[6]-Gingerol Induces Electrogenic Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1

机译：[6]-姜油通过辣椒素受体TRPV1诱导大鼠结肠的电钠吸收

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摘要

[6]-Gingerol possesses a variety of beneficial pharmacological and therapeutic properties, including anti-carcinogenic, anti-inflammatory, and anti-emetic activities. Although [6]-gingerol is known to regulate the contraction of the intestine, its effect on intestinal ion transport is unclear. The aim of this study was to examine the role of [6]-gingerol in the regulation of electrogenic ion transport in the rat intestine by measuring the transmural potential difference (Delta PD). [6]-Gingerol induced significant positive Delta PD when administered to the serosal but not mucosal side of the colon, ileum, and jejunum; the highest effect was detected in the colon at a concentration of 10 mu M. [6]-Gingerol-induced increase in Delta PD was suppressed by ouabain, an inhibitor of Na+/K+-ATPase, whereas no effect was observed in response to bumetanide, an inhibitor of the Na+-K+-2Cl(-) co-transporter. In addition, Delta PD induction by [6]-gingerol was greatly diminished by capsazepine, an inhibitor of the capsaicin receptor TRPV1. These results suggest that [6]-gingerol induced the electrogenic absorption of sodium in the rat colon via TRPV1.
机译：[6]-姜油具有多种有益的药理和治疗特性，包括抗癌，抗炎和止吐活性。尽管已知[6]-姜油醇可调节肠道的收缩，但其对肠道离子转运的作用尚不清楚。这项研究的目的是通过测量跨壁电位差（Delta PD）来研究[6]-姜油醇在大鼠肠内电离子迁移调节中的作用。 [6]-姜油在结肠，回肠和空肠的浆膜侧而非黏膜侧给药时，可诱导显着阳性的Delta PD。在浓度为10μM的结肠中检测到最高的作用。[6]-姜油诱导的Delta PD的增加被哇巴因（一种Na + / K + -ATPase的抑制剂）抑制，而未观察到对布美他尼的反应，Na + -K + -2Cl（-）共转运蛋白的抑制剂。此外，辣椒素受体TRPV1的抑制剂辣椒素大大降低了[6]-姜油对Delta PD的诱导作用。这些结果表明[6]-姜油酚通过TRPV1诱导大鼠结肠中钠的电吸收。

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