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首页> 外文期刊>Critical reviews in clinical laboratory sciences >Evaluation of glycated albumin (GA) and GA/HbA1c ratio for diagnosis of diabetes and glycemic control: A comprehensive review
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Evaluation of glycated albumin (GA) and GA/HbA1c ratio for diagnosis of diabetes and glycemic control: A comprehensive review

机译：评价糖尿病糖尿病（GA）和GA / HBA1C比率，用于诊断糖尿病和血糖控制：全面审查

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Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and non-ketotic hyperosmolar coma. In addition, possible long-term complications include impotence, nerve damage, stroke, chronic kidney failure, cardiovascular disease, foot ulcers, and retinopathy. Historically, universal methods to measure glycemic control for the diagnosis of diabetes included fasting plasma glucose level (FPG), 2-h plasma glucose (2HP), and random plasma glucose. However, these measurements did not provide information about glycemic control over a long period of time. To address this problem, there has been a switch in the past decade to diagnosing diabetes and its severity through measurement of blood glycated proteins such as Hemoglobin A1c (HbA1c) and glycated albumin (GA). Diagnosis and evaluation of diabetes using glycated proteins has many advantages including high accuracy of glycemic control over a period of time. Currently, common laboratory methods used to measure glycated proteins are high-performance liquid chromatography (HPLC), immunoassay, and electrophoresis. HbA1c is one of the most important diagnostic factors for diabetes. However, some reports indicate that HbA1c is not a suitable marker to determine glycemic control in all diabetic patients. GA, which is not influenced by changes in the lifespan of erythrocytes, is thought to be a good alternative indicator of glycemic control in diabetic patients. Here, we review the literature that has investigated the suitability of HbA1c, GA and GA: HbA1c as indicators of long-term glycemic control and demonstrate the importance of selecting the appropriate glycated protein based on the patient's health status in order to provide useful and modern point-of-care monitoring and treatment.
机译：糖尿病（DM）是一组代谢疾病，其特征是慢性高血糖浓度（高血糖）。当它被留下未经处理或不正确的管理时，它可以导致急性并发症，包括糖尿病酮症病症和非酮症过度摩尔昏迷。此外，可能的长期并发症包括阳痿，神经损伤，中风，慢性肾功能衰竭，心血管疾病，足溃疡和视网膜病变。历史上，普遍方法测量糖尿病诊断的血糖控制包括空腹血浆葡萄糖水平（FPG），2-H浆葡萄糖（2HP）和随机血浆葡萄糖。然而，这些测量没有在很长一段时间内提供有关血糖控制的信息。为了解决这个问题，通过测量血液糖化蛋白如血红蛋白A1C（HBA1C）和糖化白蛋白（GA），过去十年来诊断糖尿病及其严重程度。使用糖化蛋白的糖尿病诊断和评估具有许多优点，包括一段时间内的血糖控制的高精度。目前，用于测量糖化蛋白的常见实验室方法是高效液相色谱（HPLC），免疫测定和电泳。 HBA1C是糖尿病最重要的诊断因素之一。然而，一些报告表明，HBA1C不是适当的标记，以确定所有糖尿病患者中的血糖控制。 GA，其不受红细胞寿命的变化影响，被认为是糖尿病患者血糖控制的良好替代指标。在这里，我们审查了研究HBA1C，GA和GA：HBA1C作为长期血糖控制指标的文献，并证明了根据患者的健康状况选择适当的糖化蛋白的重要性，以提供有用和现代护理点监测和治疗。

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