• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Artificial Organs >Creatinine, Neutrophil Gelatinase-Associated Lipocalin, and Cystatin C inDetermining Acute Kidney Injury AfterHeart Operations Using CardiopulmonaryBypass
【24h】

Creatinine, Neutrophil Gelatinase-Associated Lipocalin, and Cystatin C inDetermining Acute Kidney Injury AfterHeart Operations Using CardiopulmonaryBypass

机译：肌酐，中性粒细胞明胶酶相关的脂质植物，以及胱抑素C不确定使用CardioPularyBypass的急性肾损伤的急性肾损伤

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract: Acute kidney injury (AKI) represents frequent complication after cardiac surgery using cardiopulmonary bypass (CPB), In the hope to enhance earlier more reliable characterization of AKI, we tested the utility of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC) in addition to standard creatinine for early determination of AKI after cardiac surgery using CPB. Forty-one patients met the inclusion criteria. Arterial blood samples collected after induction of general anesthesia were used as baseline, further sampling occurred at CPB termination, 2 h after CPB, on the first and second day after surgery. According to AKIN classification 18 patients (44%) developed AKI (AKI1-2 groups) and 23 (56%) did not (non-AKI group). Groups were similar regarding demographics and operative characteristics. CysC levels differed already pre-operatively (non-AKI vs. AKI2; P = 0.045; AKI1 vs. AKI2; P — 0.011), while postoperatively AKI2 group differed on the first day and AKI1 on the second regarding non-AKI group (P = 0.004; P = 0.021, respectively). NGAL and creatinine showed significant difference already 2 h after CPB between groups AKI2 and non-AKI and later on the first postoperative day between groups AKI1 and AKI2 (P = 0.028; P = 0.014, respectively). This study shows similar performance of early plasma creatinine and NGAL in patients with preserved preoperative renal function. It demonstrates that creatinine, as well as NGAL, differentiatesubsets of patients developing AKI of clinically more advanced grade early after 2 h, also when used single and uncombined.
机译：摘要：急性肾脏损伤（AKI）代表使用心肺手术（CPB）的心脏手术后经常复杂化，希望提高早期的AKI更可靠的表征，我们测试了中性粒细胞明胶酶相关脂素（NGAL）和胱抑素C的效用CYSC）除了使用CPB的心脏手术后早期测定AKI的标准肌酐。四十一名患者达到了纳入标准。在诱导全身麻醉后收集的动脉血液样本用作基线，在手术后的第一天和第二天，CPB终止，2小时发生进一步取样。根据Akin分类18例患者（44％）发达的AKI（AKI1-2组）和23（56％）没有（非AKI组）。团体与人口统计学和手术特征类似。 Cysc水平已经差异已经预先操作性（非AKI与Aki2; P = 0.045; AKI1与Aki2; P - 0.011），而术后Aki2组在第一天和Aki1关于非AKI组的第二天（P）（p = 0.004; p = 0.021）。 NGAL和CENTININE在AKI2和非AKI组之间的​​CPB后，在AKI1和AKI2组之间的第一个术后日期，患者在第一次术后日期，肌酐显示出显着差异（P = 0.028; P = 0.014）。本研究表明，在保存的术前肾功能患者中，早期血浆肌酐和NGAL的类似表现。它展示了肌酐，以及NGAL，在2小时后早期开发临床上更先进的级别的AKI的患者的患者的患者，也是如此，单身和未结合。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号