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Coffee, Caffeine, and Health Outcomes: An Umbrella Review

机译：咖啡，咖啡因和健康结果：伞审查

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摘要

To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 metaanalyses of observational studies, coffee was associated with a probable decreased risk of breast, colorectal, colon, endometrial, and prostate cancers; cardiovascular disease and mortality; Parkinson's disease; and type-2 diabetes. Of the 14 unique outcomes examined in the 20 selected meta-analyses of observational studies, caffeine was associated with a probable decreased risk of Parkinson's disease and type-2 diabetes and an increased risk of pregnancy loss. Of the 12 unique acute outcomes examined in the selected 9 metaanalyses of RCTs, coffee was associated with a rise in serum lipids, but this result was affected by significant heterogeneity, and caffeine was associated with a rise in blood pressure. Given the spectrum of conditions studied and the robustness of many of the results, these findings indicate that coffee can be part of a healthful diet.
机译：为了评估咖啡和咖啡因消费和各种健康结果之间的协会，我们对观察研究和随机对照试验（RCTS）进行了荟萃分析的证据。在选定的112个MetaAnalyses中检查的59个独特的结果中，咖啡与乳腺癌，结肠直肠癌，结肠，子宫内膜和前列腺症和前列腺癌的风险有可能相关;心血管疾病和死亡率;帕金森病;和类型2糖尿病。在20个选定的观察性研究中检查的14个独特的结果中，咖啡因与帕金森病和2型糖尿病的风险有可能降低，妊娠损失的风险增加。在所选择的RCT中检测的12个独特的急性结果中，咖啡与血清脂质的增加有关，但这种结果受到显着的异质性的影响，并且咖啡因与血压升高有关。鉴于所研究的条件和许多结果的稳健性，这些发现表明咖啡可以是健康饮食的一部分。

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