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首页> 外文期刊>Annual Review of Immunology >The Immunobiology of Interleukin-27
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The Immunobiology of Interleukin-27

机译：白细胞介素-27的免疫生理学

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摘要

Interleukin-27 (11-27) is a cytokine with strikingly diverse influences on the immune response. Although it was initially linked with the development of Th1 responses, it is now- recognized as a potent antagonist of different classes of inflammation through its ability to directly modify CD4(+) and CD8(+) Teen effector functions, to induce IL-10. and to promote specialized T regulatory cell responses. Although this aspect of IL-27 biology has provided insights into how the immune system prevents hyperactivity in the setting of infectious and autoimmune inflammation, in vaccination and cancer models the stimulatory effects of IL-27 on CD8(+) cell function appear prominent. Additionally, associations between IL-27 and antibody-mediated disease have led to an interest in defining the impact of IL-27 on innate immunity and humoral responses in different disease states. The maturation of this literature has been accompanied by attempts to translate these findings from experimental models into human diseases and by efforts to define where IL-27 might represent a viable therapeutic target.
机译：白细胞介素-27（11-27）是一种细胞因子，对免疫应答的影响很多。虽然它最初与Th1反应的发展相关联，但现在通过其直接改变CD4（+）和CD8（+）青少年效应功能来诱导IL-10的能力，令人兴奋地称为不同类别的炎症的有效拮抗剂。 。并促进专业的T调节细胞反应。虽然IL-27生物学的这一方面已经提供了对免疫系统如何阻止在传染性和自身免疫炎症的环境中的多动，但在疫苗接种和癌症模型中，IL-27对CD8（+）细胞功能的刺激作用显得突出。另外，IL-27和抗体介导的疾病之间的关联导致了对IL-27的影响定义IL-27对不同疾病状态的先天免疫和体液反应的影响。该文献的成熟伴随着试图将这些发现从实验模型转化为人类疾病，并通过努力定义IL-27可能代表可行的治疗目标的努力。

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