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首页> 外文期刊>European psychiatry: the journal of the Association of European Psychiatrists >Impact of psychotic features on morbidity and course of illness in patients with bipolar disorder.
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Impact of psychotic features on morbidity and course of illness in patients with bipolar disorder.

机译：精神病特征对躁郁症患者发病率和病程的影响。

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OBJECTIVE: In this study, we aimed to compare the clinical features and response patterns to the long-term prophylaxis of bipolar patients with or without psychotic features. METHOD: The life charts of patients with bipolar I disorder were evaluated. Two hundred and eighty-one patients who suffer with bipolar disorder for at least 4 years and who had at least three mood episodes were included to the study. The patients whose all episodes are psychotic (psychotic group) and the patients who never experienced psychotic episode (non-psychotic group) were assigned as comparison groups. The clinical features and the response to long-term prophylaxis were compared across the groups. RESULTS: The psychotic group consists of 43 patients; non-psychotic group consists of 54 patients. The history of bipolar disorder among the first-degree relatives was remarkably more prevalent in non-psychotic group (p=0.032). The predominance of manic/hypomanic episodes was significantly higher in psychotic group than non-psychotic group; and the rate of depressive episodes were higher in non-psychotic group than psychotic group (p=0.013). Episodes were more severe (p<0.001) and hospitalization rates were higher (p=0.023) in psychotic group. The response to lithium monotherapy was better in non-psychotic group (p<0.001). CONCLUSION: The well identified psychotic subtype of bipolar patients may give important predictions about long term course and prophylaxis of bipolar disorder.
机译：目的：本研究旨在比较具有或不具有精神病特征的双相型患者的长期预防的临床特征和反应模式。方法：评估双相I型障碍患者的生命图。该研究纳入了281名患有躁郁症至少4年且至少发生了3次情绪发作的患者。将所有发作均为精神病的患者（精神病组）和从未经历过精神病发作的患者（非精神病组）分配为比较组。比较各组的临床特征和对长期预防的反应。结果：精神病组包括43例患者;非精神病组由54例患者组成。一级亲属中双相情感障碍的病史在非精神病组中更为普遍（p = 0.032）。精神病组的躁狂/低躁狂发作的发生率显着高于非精神病组。非精神病组的抑郁发作率高于精神病组（p = 0.013）。精神病组发作更为严重（p <0.001），住院率较高（p = 0.023）。非精神病组对锂单药治疗的反应更好（p <0.001）。结论：公认的躁郁症患者的精神病亚型可能对躁郁症的长期病程和预防提供重要的预测。

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