首页> 外文期刊>Netherlands Journal of Zoology >INVOLVEMENT OF NEB-COLLOOSTATIN, A COLLAGEN-RELATED PEPTIDE, IN EARLY VITELLOGENESIS OF THE GREY FLESHFLY
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INVOLVEMENT OF NEB-COLLOOSTATIN, A COLLAGEN-RELATED PEPTIDE, IN EARLY VITELLOGENESIS OF THE GREY FLESHFLY

机译:NEB-胶原蛋白,胶原蛋白相关肽,在灰色果皮早期玻璃化中的参与

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摘要

During the purification procedure of the first folliculostatin of the grey fleshfly Neobellieria bullata, the Trypsin-Modulating Oostatic Factor (Neb-TMOF), a second factor with oostatic activity, was discovered. Here we report the primary structure and effects on oocyte development of the latter factor. The amino acid sequence was determined as H-SIVPLGLPVPIGPIVVGPR-OH. Because of structural sequence similarities with parts of several known collagens and because of its oostatic activity, we named the factor Neb-colloostatin. The synthetic peptide inhibits yolk uptake by previtellogenic oocytes and might be the factor thai determines that per ovariole only one follicle develops at a time.
机译:在灰色果蝇新鞭毛虫的第一个卵泡抑素的纯化过程中,发现了具有促卵泡活性的第二个因子胰蛋白酶调节的促卵泡因子(Neb-TMOF)。在这里,我们报告后一个因素的主要结构及其对卵母细胞发育的影响。氨基酸序列确定为H-SIVPLGLPVPIGPIVVGPR-OH。由于与几种已知胶原蛋白的部分结构序列相似,并且由于其具有镇静作用,我们将其命名为Neb-colloostatin因子。合成的肽抑制卵原性卵母细胞摄取卵黄,可能是决定每个卵巢一次只能发育一个卵泡的因素。

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