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首页> 外文期刊>Journal of King Saud University >In vitro evaluation of the efficacy of deferoxamine against Leishmania major life cycle stages
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In vitro evaluation of the efficacy of deferoxamine against Leishmania major life cycle stages

机译：体外评估去铁胺对大利什曼原虫生命周期阶段的疗效

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Many regions of the world, including Saudi Arabia, are medically vulnerable by the spread of leishmaniasis. Although the effectiveness, the current available drugs suffer from the appearance of resistant strains in epidemic areas and their toxic side-effects. We report the use of the iron chelator deferoxamine (DFRX) that can be used as antileishmanial agents. Our experimental procedure was to follow up the growth of Leishmania major stages (extracellular promastigotes, exinic extracellular amastigotes and intracellular amastigotes) in presence of the tested compound in the culture media in different concentrations (10 μg/ml, 25 μg/ml, 50 μg/ml and no treatment) and comparing it to the untreated control. The compound showed antileishmanial activities as it showed great activity against the growth of the three Leishmania stages in a time and dose dependent manner. Finally, this compound shows a promising potential activity to be a possible antileishmanial compound alternatively or in combination with the currently used drugs.
机译：利什曼病的传播使世界上许多地区（包括沙特阿拉伯）在医疗上都处于脆弱状态。尽管是有效的，但是当前可用的药物在流行区出现抗药性菌株并具有毒副作用。我们报告了可用作螯合剂的铁螯合剂去铁胺（DFRX）的使用。我们的实验程序是在存在不同浓度（10μg/ ml，25μg/ ml，50μg）的被测化合物的情况下，追踪利什曼原虫主要阶段（细胞外前鞭毛体，外源性胞外羊膜炎和细胞内羊膜炎）的生长。 / ml且未处理），并将其与未处理的对照进行比较。该化合物表现出抗衰老活性，因为它以时间和剂量依赖的方式显示出对三个利什曼原虫生长的抑制作用。最后，该化合物显示出有希望的潜在活性，可替代或与当前使用的药物组合成为可能的抗疟疾化合物。

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