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首页> 外文期刊>Pharmacogenetics and genomics >Susceptibility to urinary bladder cancer: relevance of rs9642880(T), GSTM1 0/0 and occupational exposure.
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Susceptibility to urinary bladder cancer: relevance of rs9642880(T), GSTM1 0/0 and occupational exposure.

机译：膀胱癌的易感性：rs9642880（T），GSTM1 0/0和职业暴露的相关性。

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Recently, a genome-wide single nucleotide polymorphism association study has identified a sequence variant 30 kb upstream of the c-Myc gene (allele T of rs9642880) that confers susceptibility to bladder cancer. However, the role of exposure to bladder carcinogens has not been considered. This prompted us to analyse the relevance of this polymorphism in 515 bladder cancer cases and 893 controls where the quality and quantity of occupational exposure to bladder carcinogens has been documented. When we analysed a hospital-based case-control series not selected for occupational exposure, rs9642880[T] was influential, in contrast to GSTM1 0/0. However, in a case-control series of patients that have been occupationally exposed to aromatic amines and polycyclic aromatic hydrocarbons, rs9642880[T] was not influential but GSTM1 0/0 was significantly associated with bladder cancer risk. Therefore, the degree to which rs9642880[T] and GSTM1 0/0 confer susceptibility to urinary bladder cancer seems to depend on the extent of exposure to urinary bladder carcinogens.
机译：最近，一项全基因组范围的单核苷酸多态性关联研究已经确定了c-Myc基因（rs9642880的等位基因T）上游30 kb的序列变异，该变异赋予膀胱癌易感性。但是，尚未考虑暴露于膀胱致癌物的作用。这促使我们在515例膀胱癌病例和893例对照中分析了这种多态性的相关性，这些病例已记录了职业暴露于膀胱致癌物的质量和数量。当我们分析未选择用于职业暴露的基于医院的病例对照系列时，与GSTM1 0/0相比，rs9642880 [T]具有影响力。然而，在一系列病例对照研究中，职业接触过芳香胺和多环芳烃的患者，rs9642880 [T]没有影响，但GSTM1 0/0与膀胱癌风险显着相关。因此，rs9642880 [T]和GSTM1 0/0赋予膀胱癌敏感性的程度似乎取决于暴露于膀胱致癌物的程度。

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