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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation and evaluation of easy energy supply property of medium-chain fatty acids liposomes
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Preparation and evaluation of easy energy supply property of medium-chain fatty acids liposomes

机译：中链脂肪酸脂质体易供性的制备与评价

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摘要

To develop an easy-energy-supply agent, medium-chain fatty acids (MCFAs) liposomes were prepared by thin-layer dispersion, freeze-thawing and dynamic high pressure microfluidization (DHPM)-freeze-thawing methods. Results showed that MCFAs nanoliposomes obtained by the novel method (DHPM-freeze-thaw-ing) exhibited a smaller size (72.6 ±4.9 nm), narrower size distribution (PDI = 0.175 ±0.005), higher zeta potential (-41.27 ± 1.16 mV) and entrapment efficiency (45.9 ± 6.0%) compared to the other two methods. In the weight-loaded swimming test of the mice, the high-dose group of MCFAs nanoliposomes indicated a significantly longer swimming time (105±31min, p < 0.05), a lower serum urea nitrogen (839.5 ±111.9 mg/L, p < 0.05) and blood lactic acid (5.7 ± 1.0 mmol/L, p≤ 0.001), and a higher hepatic glycogen (15.0 ± 3.6 mg/g, p≤ 0.001) than those of the control group (53±13min, 1153.6 ± 102.5 mg/L, 12.5 ± 1.9 mmol/L and 8.8 ± 3.3 mg/g, respectively). However, no significant difference was found between the high-dose group and MCFAs group. The results suggested that MCFAs nanoliposomes could be used as a potential easy-energy-supply agent.
机译：为了开发易耗能剂，通过薄层分散，冻融和动态高压微流化（DHPM）-冻融方法制备了中链脂肪酸（MCFAs）脂质体。结果表明，通过新方法（DHPM冻融）获得的MCFAs纳米脂质体具有较小的尺寸（72.6±4.9 nm），较窄的尺寸分布（PDI = 0.175±0.005）和较高的ζ电位（-41.27±1.16 mV） ）和包封率（45.9±6.0％）相比其他两种方法。在小鼠的负重游泳实验中，高剂量的MCFAs纳米脂质组显示出明显更长的游泳时间（105±31min，p <0.05），较低的血清尿素氮（839.5±111.9 mg / L，p < 0.05）和血液乳酸（5.7±1.0 mmol / L，p≤0.001），肝糖原（15.0±3.6 mg / g，p≤0.001）高于对照组（53±13min，1153.6±102.5） mg / L，12.5±1.9 mmol / L和8.8±3.3 mg / g）。但是，高剂量组和MCFAs组之间没有发现显着差异。结果表明，MCFAs纳米脂质体可用作潜在的易耗能剂。

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