Nickel-Catalyzed Site-Selective Amidation of Unactivated C(sp~3)-H Bonds

Xuesong Wu; Yan Zhao; Haibo Ge

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Nickel-Catalyzed Site-Selective Amidation of Unactivated C(sp~3)-H Bonds

机译：未活化的C（sp〜3）-H键的镍催化位点选择性酰胺化

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Intramolecular dehydrogenative cyclization of aliphatic amides was achieved on unactivated sp~3 carbon atoms by a nickel-catalyzed C-H bond functionalization process with the assistance of a bidentate directing group. The reaction favors the C-H bonds of β-methyl groups over the γ-methyl or β-methylene groups. Additionally, a predominant preference for the β-methyl C-H bonds over the aromatic sp~2 C-H bonds was observed. Moreover, this process also allows for the effective functionalization of benzylic secondary sp~3 C-H bonds.

机译：脂族酰胺的分子内脱氢环化反应是通过镍催化的C-H键官能化过程以及双齿导向基团在未活化的sp〜3碳原子上实现的。与γ-甲基或β-亚甲基相比，该反应有利于β-甲基的C-H键。另外，观察到相对于芳香族sp〜2 C-H键，β-甲基C-H键具有更大的优势。而且，该方法还允许苄基仲sp 3 C-H键的有效官能化。

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《Chemistry: A European journal》 |2014年第31期|共4页
作者
Xuesong Wu; Yan Zhao; Haibo Ge;
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正文语种 eng
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amidation; C-H bond functionalization; nickel; site selectivity; β-lactams;

机译：酰胺化;C-H键官能化;镍;位点选择性;β-内酰胺类;

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1. Nickel-Catalyzed Site-Selective Amidation of Unactivated C(sp(3))-H Bonds (vol 20, pg 9530, 2014) [J] . Wu X., Zhao Y., Ge H. Chemistry: A European journal . 2015,第4期

机译：未活化的C（sp（3））-H键的镍催化位点选择性酰胺化（第20卷，第9530页，2014年）
2. Nickel-Catalyzed Site-Selective Amidation of Unactivated C(sp~3)-H Bonds [J] . Xuesong Wu, Yan Zhao, Haibo Ge Chemistry: A European journal . 2014,第31期

机译：未活化的C（sp〜3）-H键的镍催化位点选择性酰胺化
3. Nickel-Catalyzed Site-Selective Alkylation of Unactivated C(sp~3)-H Bonds [J] . Xuesong Wu, Yan Zhao, Haibo Ge Journal of the American Chemical Society . 2014,第5期

机译：镍催化未激活的C（sp〜3）-H键的位点选择性烷基化
4. Surface plasmon resonance (SPR) sensing based on DNA elongation by site-selective surface plasmon (SP) field heating toward ultra-high sensitive detection of single pathogenic particles [C] . Yuki Kawahara, Akito Ishida PRiME Joint International Meeting of the Electrochemical Society, the Electrochemical Society of Japan, and the Korean Electrochemical Society . 2016

机译：基于DNA伸长的位点选择性表面等离子体（SP）场加热朝向单一致病颗粒的超高敏感检测，表面等离子体共振（SPR）感测
5. Part I: Asymmetric synthesis of alpha-allyl-alpha-aryl alpha-amino acids. Part II: Asymmetric spirocyclization of allenyl ketones. Part III: Chemoselective activation of C(sp3)--H bond over C(sp 2)--H bond with Pd(II). [D] . Curto, John M. 2014

机译：第一部分：α-烯丙基-α-芳基α-氨基酸的不对称合成。第二部分：烯基酮的不对称螺环化。第三部分：与Pd（II）相比，C（sp3）-H键的化学选择性活化。
6. Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp3)–H bonds with acetonitrile [O] . Yongbing Liu, Ke Yang, Haibo Ge 2016

机译：钯催化未活化的C（sp3）–H键与乙腈的配位体促进位点选择性氰甲基化
7. Intermolecular amidation of unactivated sp2 and sp3 C-H bonds via palladium-catalyzed cascade C-H activation/nitrene insertion [O] . Thu HY, Yu WY, Che CM 2006

机译：未激活的sp2和sp3 C-H键的分子间酰胺化作用，通过钯催化的级联C-H激活/硝烯插入

Nickel-Catalyzed Site-Selective Amidation of Unactivated C(sp~3)-H Bonds

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