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首页> 外文期刊>Annual Review of Immunology >Chromatin-Modifying Enzymes in T Cell Development
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Chromatin-Modifying Enzymes in T Cell Development

机译：T细胞发育中的染色质改性酶

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摘要

T cell development involves stepwise progression through defined stages that give rise to multiple T cell subtypes, and this is accompanied by the establishment of stage-specific gene expression. Changes in chromatin accessibility and chromatin modifications accompany changes in gene expression during T cell development. Chromatin-modifying enzymes that add or reverse covalent modifications to DNA and histones have a critical role in the dynamic regulation of gene expression throughout T cell development. As each chromatin-modifying enzyme has multiple family members that are typically all coexpressed during T cell development, their function is sometimes revealed only when two related enzymes are concurrently deleted. This work has also revealed that the biological effects of these enzymes often involve regulation of a limited set of targets. The growing diversity in the types and sites of modification, as well as the potential for a single enzyme to catalyze multiple modifications, is also highlighted.
机译：T细胞显影涉及通过产生多个T细胞亚型的定义阶段的逐步进展，并且这伴随着建立阶段特异性基因表达。染色质可移性和染色质修饰的变化伴随着T细胞发育过程中基因表达的变化。添加或反转与DNA和组蛋白的共价修饰的染色质调节酶在T细胞发育过程中基因表达的动态调节中具有关键作用。由于每种染色质调节酶具有多种通常在T细胞发育过程中共相交的家族构件，仅当两种相关酶同时删除时，它们的功能有时仅揭示。这项工作还透露，这些酶的生物学效应往往涉及调节一组有限的靶标。还突出了改性类型和部位的变化，以及单一酶催化多种修改的潜力。

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