...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Oral diseases >Role of lactoferrin and lactoferrin‐derived peptides in oral and maxillofacial diseases
【24h】

Role of lactoferrin and lactoferrin‐derived peptides in oral and maxillofacial diseases

机译：乳铁蛋白和乳蛋白衍生肽在口腔和颌面疾病中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The oral cavity harbors different taxonomic groups, the evolutionary coexistence of which develops the oral ecosystem. These resident microorganisms can alter the balance between the physiologic and pathologic conditions that affect the host, both locally and systemically. This highly sophisticated nature of the oral cavity poses a significant therapeutic challenge. Numerous human and animal studies have been conducted to potentiate the efficacy and competence of current treatments of pathologic conditions as well as to develop novel therapeutic modalities. One of these studies is the use of the potent antimicrobial agent lactoferrin ( LF ), which was originally derived from the host immune system. LF is an 80‐kDa glycoprotein that has a free iron sequestration mechanism with evident antimicrobial, anti‐tumor, and immunomodulatory properties. A wide range of active peptides have been isolated from the N‐terminal region of LF , which possess antimicrobial activities. In this review, we discuss the role of LF and LF ‐derived peptides under a heterogeneous group of oral and maxillofacial conditions, including bacterial, fungal, viral infections; head and neck cancers; xerostomia; and implantology‐bone‐related manifestations.
机译：口腔留下不同的分类群，其进化共存产生了口腔生态系统。这些驻留的微生物可以改变在本地和系统性地影响主体的生理和病理条件之间的平衡。口腔的这种高度复杂的性质构成了显着的治疗挑战。已经进行了许多人类和动物研究，以提高当前病理病症治疗的疗效和能力以及开发新的治疗方式。这些研究之一是使用最初来自宿主免疫系统的有效抗微生物剂乳蛋白（LF）。 LF是一种80-kda糖蛋白，具有可用的铁螯合机制，具有明显的抗微生物，抗肿瘤和免疫调节性能。从LF的N-末端区域中分离出广泛的活性肽，其具有抗微生物活性。在本综述中，我们讨论了LF和LF相位的肽在非均相口腔和颌面裂变条件下的作用，包括细菌，真菌，病毒感染;头部和颈部癌; Xerostomia;和植入学 - 与骨骼相关的表现形式。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号