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首页> 外文期刊>DTW:Deutsche Tierarztliche Wochenschrift >Concentrations of beta -carotene (CarofertinReg.) and vitamin A in plasma of pigs after intramuscular injection of beta -carotene.
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Concentrations of beta -carotene (CarofertinReg.) and vitamin A in plasma of pigs after intramuscular injection of beta -carotene.

机译：肌内注射β-胡萝卜素后，猪血浆中β-胡萝卜素（CarofertinReg。）和维生素A的浓度。

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摘要

Limited information is available about the absorption and distribution of parenterally administered beta -carotene in pigs. Therefore, plasma concentrations and pharmacokinetic parameters of beta -carotene, its influence on plasma vitamin A concentration as well as the safety and tolerability of an intramuscularly administered beta -carotene preparation (Carofertin) were analysed. Five gilts were injected with a single dose of 70 mg beta -carotene in an injectable aqueous solution. The mean pretreatment plasma beta -carotene concentration was below 10 micro g/ml. After injection, the plasma beta -carotene values increased rapidly and reached a peak of 13.8+or-5.4 micro g/ml after 24 h. For a duration of 72 h, the plasma beta -carotene concentrations were significantly increased compared to the baseline values (p<0.05). The mean half life of beta -carotene in plasma was 7.2+or-1.4 h. The single dose of 70 mg beta -carotene insignificantly affected the plasma vitamin A concentrations. Tolerability and safety of the administered preparation were good. No side effects related to the medication were observed.
机译：关于肠胃外施用的β-胡萝卜素在猪中的吸收和分布的信息有限。因此，分析了β-胡萝卜素的血浆浓度和药代动力学参数，其对血浆维生素A浓度的影响以及肌肉内给药的β-胡萝卜素制剂（Carofertin）的安全性和耐受性。在可注射的水溶液中，给五只小母猪注射单剂量的70 mgβ-胡萝卜素。预处理血浆β-胡萝卜素的平均浓度低于10微克/毫升。注射后，血浆β-胡萝卜素值迅速增加，并在24小时后达到13.8+或-5.4 micro g / ml的峰值。与基线值相比，在72小时内，血浆β-胡萝卜素浓度显着增加（p <0.05）。血浆中β-胡萝卜素的平均半衰期为7.2+或-1.4 h。 70 mgβ-胡萝卜素的单次剂量对血浆维生素A浓度的影响很小。给药制剂的耐受性和安全性良好。没有观察到与药物相关的副作用。

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