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首页> 外文期刊>DTW:Deutsche Tierarztliche Wochenschrift >Concentrations of beta-carotene (Carofertin (R)) and vitamin A in plasma of pigs after intramuscular injection of beta-carotene
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Concentrations of beta-carotene (Carofertin (R)) and vitamin A in plasma of pigs after intramuscular injection of beta-carotene

机译：肌肉注射β-胡萝卜素后，猪血浆中β-胡萝卜素（Carofertin（R））和维生素A的浓度

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摘要

Limited information is available about the absorption and distribution of parenterally administered beta-carotene in pigs. Therefore plasma concentrations and pharmacokinetic parameters of beta-carotene, its influence on plasma vitamin A concentration as well as the safety and tolerability of an intramuscularly administered beta-carotene preparation (Carofertin (R)) were analysed. Five gilts were injected with a single dose of 70 ning beta-carotene in an injectable aqueous Solution. The mean pre-treatment plasma beta-carotene concentration was below 10 mu g/ml. After injection, plasma beta-carotene values increased rapidly and reached a peak of 13.8 +/- 5.4 mu g/ml after 24 hours. For a duration of 72 hours, plasma beta-carotene concentrations were significantly increased compared to baseline values (p < 0.05). The mean half-life of beta-carotene in plasma was 7.2 +/- 1.4 hours. The single dose of 70 mg beta-carotene did not significantly affect plasma vitamin A concentrations. Tolerability and safety of the administered preparation were good. No side effects related to the medication were observed,
机译：关于肠胃外施用的β-胡萝卜素在猪中的吸收和分布的信息有限。因此，分析了β-胡萝卜素的血浆浓度和药代动力学参数，其对血浆维生素A浓度的影响以及肌肉内给药的β-胡萝卜素制剂（Carofertin（R））的安全性和耐受性。在可注射的水溶液中向五只小母猪注射单剂量的70 ningβ-胡萝卜素。治疗前血浆β-胡萝卜素的平均浓度低于10μg / ml。注射后，血浆β-胡萝卜素值迅速增加，并在24小时后达到峰值13.8 +/- 5.4μg / ml。与基线值相比，在72小时内，血浆β-胡萝卜素浓度显着增加（p <0.05）。 β-胡萝卜素在血浆中的平均半衰期为7.2 +/- 1.4小时。单次服用70毫克β-胡萝卜素不会显着影响血浆维生素A的浓度。给药制剂的耐受性和安全性良好。没有观察到与药物相关的副作用，

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