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首页> 外文期刊>Microbial Pathogenesis >Production, characterization and antibacterial activity of silver nanoparticles produced by Fusarium oxysporum and monitoring of protein-ligand interaction through in-silico approaches
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Production, characterization and antibacterial activity of silver nanoparticles produced by Fusarium oxysporum and monitoring of protein-ligand interaction through in-silico approaches

机译：通过镰刀酸镰刀菌制造的银纳米粒子的生产，表征和抗菌活性，并通过硅蛋白 - 配体相互作用通过硅基方法进行监测

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摘要

The present study envisages biological production of silver nanoparticles using Fusarium oxysporum and in-silico identification of the antibacterial activity of the nanoparticles using protein-ligand interaction studies. The morphology of the nanoparticles was variable, with majority of them spherical in the size range 1-50 nm. For insilico studies, two microorganisms, Escherichia coli and Pseudomonas aeruginosa were selected and metal docking was carried out using the licensed software SYBYL X 1.1.1. The ligand docked deeply into the binding pockets of the outer membrane proteins (OMPs) of both E. coli and P. aeruginosa. The results showed that silver may prove to be a strong antibacterial agent against both the pathogens, with the antibacterial action of silver being greater in the case of P. aeruginosa. The results obtained through in-silico studies were further validated by in-vitro approaches on both solid and liquid media to confirm the results obtained by in-silico analysis. The corroboration of in-silico and in-vitro results amply demonstrates the immense antibacterial potential of silver nanoparticles against the selected pathogens.
机译：本研究设想使用蛋白酶 - 配体相互作用研究使用镰刀虫氧化孢子子和硅鉴定银纳米粒子的生物生产。纳米颗粒的形态是可变的，其中大部分为1-50nm的大小球形。对于Insilico研究，选择了两种微生物，大肠杆菌和假单胞菌铜绿假单胞菌，并使用持牌软件Sybyl X 1.1.1进行金属对接。配体深深地对接到大肠杆菌和P.铜绿假单胞菌的外膜蛋白（OMP）的粘合口袋中。结果表明，银可以证明是对病原体的强抗菌剂，在P.铜绿假单胞菌的情况下，银具有更大的抗菌作用。通过固体和液体培养基上的体外方法进一步验证通过硅基研究得到的结果，以确认通过硅藻分析获得的结果。二氧化硅和体外结果的粗化充分地证明了银纳米粒子对所选病原体的巨大抗菌电位。

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