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首页> 外文期刊>AIDS Research and Human Retroviruses >Near full-length sequence analysis of two new HIV type 1 unique (CRF01-AE/B) recombinant frms among men who have sex with men in China
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Near full-length sequence analysis of two new HIV type 1 unique (CRF01-AE/B) recombinant frms among men who have sex with men in China

机译：中国男男性接触者中两个新的HIV 1型独特（CRF01-AE / B）重组新序列的近乎全长序列分析

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摘要

Recombination contributes substantially to the genetic diversity of HIV-1, and is likely to occur in populations in which multiple subtypes circulate. Molecular epidemiological studies showed that subtype B, CRF01-AE, and CRF07-BC are currently circulating in parallel among men who have sex with men (MSM) in China, suggesting the possible emergence of new recombinants. In the present study, we identified two new HIV Type 1 unique (CRF01-AE /B) recombinant forms in this population by near full-length genomic analysis. Our data provided the first description of the near full-length genomes of these new CRF01-AE/B recombinants as well as important insights into the complexity of HIV-1 recombinant strains currently in circulation among MSM in China. These data highlight the importance of continuous surveillance of the dynamic change of HIV-1 subtypes and new recombinants among the MSM population.
机译：重组在很大程度上促进了HIV-1的遗传多样性，并且可能发生在多种亚型流通的人群中。分子流行病学研究表明，B型，CRF01-AE和CRF07-BC目前在中国与男男性接触者（MSM）中平行传播，这表明可能出现新的重组体。在本研究中，我们通过近乎全长的基因组分析，在该人群中鉴定了两种新的HIV 1型独特（CRF01-AE / B）重组形式。我们的数据首次提供了这些新的CRF01-AE / B重组体近乎全长基因组的描述，以及对中国MSM中目前正在传播的HIV-1重组株的复杂性的重要见解。这些数据凸显了持续监测MSM人群中HIV-1亚型和新重组子动态变化的重要性。

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