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Resistant starch opposes colonic DNA damage induced by dairy and non-dairy dietary protein

机译:抗性淀粉抵抗乳制品和非乳制品饮食蛋白引起的结肠DNA损伤

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Recent epidemiological evidence suggests that consumption of diets high in red or processed meats and low in dietary fibre may contribute to the high incidence of colorectal disease in western societies. To increase our understanding of the dietary factors which could contribute to colorectal diseases we have carried out a series of studies using rats to examine the effects of consuming high levels of a range of different dietary proteins, with and without resistant starch (RS), on colonic health markers. We have shown that dietary protein sources differ in their capacity to increase colonic DNA damage and mucus barrier thinning but that inclusion of RS in the diet protected completely or partly against these effects. High levels of dietary casein increased DNA damage but the damage was not as great as for cooked beef or a soy isolate. A whey protein isolate did not increase colonic DNA damage when consumed at high levels. Our results suggest that dietary protein of dairy origin may be less harmful to the integrity of the large bowel than a number of other protein sources and also that addition of RS to the diet appears to counteract protein-induced damage irrespective of the source.
机译:最近的流行病学证据表明,食用红色或加工肉含量高而膳食纤维含量低的饮食可能会导致西方社会大肠疾病的高发。为了加深我们对可能导致大肠疾病的饮食因素的了解,我们进行了一系列研究,使用大鼠来研究食用高水平的各种不同饮食蛋白(含或不含抗性淀粉(RS))的影响。结肠健康标志。我们已经表明,膳食蛋白质来源在增加结肠DNA损伤和粘液屏障变薄的能力上有所不同,但是在饮食中添加RS可以完全或部分保护这些作用。高含量的酪蛋白饮食会增加DNA损伤,但损伤不如煮熟的牛肉或大豆分离株。乳清蛋白分离物在高水平食用时不会增加结肠DNA损伤。我们的研究结果表明,与许多其他蛋白质来源相比,乳制品来源的饮食蛋白质对大肠完整性的危害可能较小,而且无论饮食来源如何,在饮食中添加RS似乎都能抵消蛋白质引起的损害。

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